Allogeneic Hemopietic Stem Cell Transplants for the Treatment of B Cell Acute Lymphocytic Leukemia

Dong, Wei-Min; Cao, Xiang-Shan; Wang, Biao; Lin, Yun; Hua, Xiao-Ying; Qiu, Guo-Qiang; Gu, Wei-Ying; Xie, Xiao-Bao

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저자정보: Dong, Wei-Min (Department of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University) Cao, Xiang-Shan (Department of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University) Wang, Biao (Department of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University) Lin, Yun (Department of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University) Hua, Xiao-Ying (Department of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University) Qiu, Guo-Qiang (Department of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University) Gu, Wei-Ying (Department of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University) Xie, Xiao-Bao (Department of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suzhou University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제15호

발행연도: 2014.1

수록면: 6,127 - 6,130 (4page)

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Objective: Explore the feasibility of allo-hemopietic stem cell transplants in treating patients with B cell acute lymphocytic leukemia. Methods: Between september 2006 and February 2011, fifteen patients with B cell acute lymphocytic leukemia (ALL) were treated by allo-hemopietic stem cell transplants (HSCT). Stem cell sources were peripheral blood. Six patients were conditioned by busulfan (BU) and cyclophosphamide (CY) and nine patients were conditioned with TBI and cyclophosphamide (CY). Graft versus host disease (GVHD) prophylaxis regimen consisted of cyclosporine A (CSA), methotrex ate (MTX) and mycophenolatemofetil (MMF). Results: Patients received a median of $7.98{\times}10^8{\cdot}kg^{-1}$ ($5.36-12.30{\times}10^8{\cdot}kg^{-1}$) mononuclear cells (MNC). The median time of ANC> $0.5{\times}10^9/L$ was day 12 (10-15), and PLT> $20.0{\times}10^9/L$ was day 13 (11-16). Extensive acute GVHD occurred in 6 (40.0%) patients, and extensive chronic GVHD was recorded in 6 (40.0%) patients. Nine patients were alive after 2.5-65 months follow-up. Conclusion: Allogeneic stem cell transplant could be effective in treating patients with B cell acute lymphocytic leukemia.

#Hematopoietic stem cell transplants #acute lymphocyti leukemia

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Dong, Wei-Min

소속기관 Department of Hematology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Suz