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자료유형
학술저널
저자정보
Ghafouri-Fard, Soudeh (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences) Rezazadeh, Fatemeh (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences) Zare-Abdollahi, Davood (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences) Omrani, Mir Davood (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences) Movafagh, Abolfazl (Department of Medical Genetics, Shahid Beheshti University of Medical Sciences)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제18호
발행연도
2014.1
수록면
7,703 - 7,705 (3page)

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Cancer-testis (CT) antigens are a group of tumor-associated antigens with restricted expression in normal tissues except for testis and expression in a wide variety of tumor tissues. This pattern of expression makes them suitable targets for immunotherapy as well as potential biomarkers for early detection of cancer. However, some genes attributed to this family are now known to be expressed in other normal tissues which put their potential applications in immunotherapy and cancer detection under question. Here we analyzed expression of two previously known CT antigens, RHOXF2 and PIWIL2, in AML patients versus normal donors and found no significant difference in the expression of these genes between the two groups. As these two genes showed expression in normal leukocytes, their expression pattern seems to be wider than to be attributed to the CT gene family. Future research should focus on the expression profiles of so called CT antigens to find those with more testis specific expression.

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