Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

Ren, Yan; Kitahara, Cari Meinhold; de Gonzalez, Amy Berrington; Clero, Enora; Brindel, Pauline; Maillard, Stephane; Cote, Suzanne; Dewailly, Eric; Rachedi, Frederique; Boissin, Jean-Louis; Sebbag, Joseph; Shan, Larrys; Bost-Bezeaud, Frederique; Petitdidier, Patrick; Xhaard, Constance; Rubino, Carole; de Vathaire, Florent

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저자정보: Ren, Yan (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health [CESP]) Kitahara, Cari Meinhold (Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) de Gonzalez, Amy Berrington (Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) Clero, Enora (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health [CESP]) Brindel, Pauline (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health [CESP]) Maillard, Stephane (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health [CESP]) Cote, Suzanne (Area of population health and optimal health practices, CHU de Quebec Research Center) Dewailly, Eric (Area of population health and optimal health practices, CHU de Quebec Research Center) Rachedi, Frederique (Territorial Hospital Mamao) Boissin, Jean-Louis (IPRAME) Sebbag, Joseph (Paofai Clinic) Shan, Larrys (Endocrinologist) Bost-Bezeaud, Frederique (Territorial Hospital Mamao) Petitdidier, Patrick (Laboratoire Boz) Xhaard, Constance (Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health [CESP]) Rubino, Carole (Radiation) de Vathaire, Florent

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제13호

발행연도: 2014.1

수록면: 5,187 - 5,194 (8page)

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Background: Numerous studies have suggested that selenium deficiency may be associated with an increased risk for several types of cancer, but few have focused on thyroid cancer. Materials and Methods: We examined the association between post-diagnostic fingernail selenium levels and differentiated thyroid cancer risk in a French Polynesian matched case-control study. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Results: The median selenium concentration among controls was $0.76{\mu}g/g$. Significantly, we found no association between fingernail selenium levels and thyroid cancer risk after conditioning on year of birth and sex and additionally adjusting for date of birth (highest versus lowest quartile: odds-ratio=1.12, 95% confidence interval: 0.66-1.90; p-trend=0.30). After additional adjustment for other covariates, this association remained non-significant (p-trend=0.60). When restricting the analysis to thyroid cancer of 10 mm or more, selenium in nails was non-significantly positively linked to thyroid cancer risk (p-trend=0.09). Although no significant interaction was evidenced between iodine in nails and selenium in nails effect (p=0.70), a non-significant (p-trend =0.10) positive association between selenium and thyroid cancer risk was seen in patients with less than 3 ppm of iodine in nails. The highest fingernail selenium concentration in French Polynesia was in the Marquises Islands ($M=0.87{\mu}g/g$) and in the Tuamotu-Gambier Archipelago ($M=0.86{\mu}g/g$). Conclusions: Our results do not support, among individuals with sufficient levels of selenium, that greater long-term exposure to selenium may reduce thyroid cancer risk. Because these findings are based on post-diagnostic measures, studies with prediagnostic selenium are needed for corroboration.

#Thyroid cancer #selenium #diet #fingernail #case-control study

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Ren, Yan

소속기관 Radiation Epidemiology Group, Centre for Research in Epidemiology and Population Health [CESP]