Dopamine Receptor Gene (DRD1-DRD5) Expression Changes as Stress Factors Associated with Breast Cancer

Pornour, Majid; Ahangari, Ghasem; Hejazi, Seyed Hesam; Ahmadkhaniha, Hamid Reza; Akbari, Mohamad Esmail

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저자정보: Pornour, Majid (Neuroimmunopsychooncogenetic Group, Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology) Ahangari, Ghasem (Neuroimmunopsychooncogenetic Group, Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology) Hejazi, Seyed Hesam (Neuroimmunopsychooncogenetic Group, Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology) Ahmadkhaniha, Hamid Reza (Tehran Institute of Psychiatry, Mental Health Research Center, Iran University of Medical Sciences) Akbari, Mohamad Esmail (Department of Cancer Surgery, Cancer Research Center, Shohada Hospital ShahidBeheshti, Shahid Beheshti University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제23호

발행연도: 2014.1

수록면: 10,339 - 10,343 (5page)

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Breast cancer is the most common cancer among females worldwide and a most prevalent malignancy in Iranian women. Chronic stress may make an important contribution to cancer, especially in the breast. Numerous studies showed roles of neurotransmitters in the occurrence and progression of cancers which are mediated by their various types of receptors. This study was conducted to evaluate alterations in the expression profile of dopamine receptor genes in peripheral blood mononuclear cells (PBMC) as stress factors in breast cancer patients and the human breast cancer cell line (MCF-7). Peripheral blood samples were obtained from 30 patients and 30 healthy individuals. Total mRNA was extracted from PBMC and MCF-7 cells and RT-PCR was performed to confirm the presence of five dopamine receptors (DRD1-DRD5). Expression changes of dopamine receptor genes were evaluated by real time PCR. We observed that DRD2-DRD4 in PBMCs of breast cancer patients were increased compared to healthy individuals. In addition, all dopamine receptor subtypes but DRD1 were expressed in MCF-7 cells. Therefore, alterations of these receptors as stress factors should be assessed for selecting appropriate drugs such as D2-like agonists for treatment of breast cancer after performing complimentary tests. Determining the expression profile of dopamine receptor genes thus seems promising.

#Stress #breast cancer #dopamine receptors #gene expression #neurotransmitters #peripheral blood cells

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Pornour, Majid

소속기관 Neuroimmunopsychooncogenetic Group, Department of Medical Genetics, National Institute of Genetic En