Characterisation and Clinical Significance of FLT3-ITD and non-ITD in Acute Myeloid Leukaemia Patients in Kelantan, Northeast Peninsular Malaysia

Yunus, Noraini Mat; Johan, Muhammad Farid; Al-Jamal, Hamid Ali Nagi; Husin, Azlan; Hussein, Abdul Rahim; Hassan, Rosline

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자료유형: 학술저널

저자정보: Yunus, Noraini Mat (Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia) Johan, Muhammad Farid (Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia) Al-Jamal, Hamid Ali Nagi (Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia) Husin, Azlan (Haemato-Oncology Unit, Department of Internal Medicine, School of Medical Sciences, Universiti Sains Malaysia) Hussein, Abdul Rahim (Advanced Medical And Dental Institute, Universiti Sains Malaysia) Hassan, Rosline (Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제12호

발행연도: 2015.1

수록면: 4,869 - 4,872 (4page)

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Background: Mutations of the FMS-like tyrosine kinase-3 (FLT3) receptor gene may promote proliferation via activation of multiple signaling pathways. FLT3-internal tandem duplication (FLT3-ITD) is the most common gene alteration found in patients diagnosed with acute myeloid leukaemia (AML) and has been associated with poor prognosis. Materials and Methods: We performed mutational analysis of exons 14-15 and 20 of the FLT3 gene in 54 AML patients using PCR-CSGE (conformational sensitive gel electrophoresis) followed by sequencing analysis to characterise FLT3 mutations in adult patients diagnosed with AML at Hospital USM, Kelantan, Northeast Peninsular Malaysia. Results: FLT3 exon 14-15 mutations were identified in 7 of 54 patients (13%) whereas no mutation was found in FLT3 exon 20. Six ITDs and one non-ITD mutation were found in exon 14 of the juxtamembrane (JM) domain of FLT3. FLT3-ITD mutations were associated with a significantly higher blast percentage (p-value = 0.008) and white blood cell count (p-value = 0.023) but there was no significant difference in median overall survival time for FLT3-ITD+/FLT3-ITD- within 2 years (p-value = 0.374). Conclusions: The incidence of FLT3-ITD in AML patients in this particular region of Malaysia is low compared to the Western world and has a significant association with WBC and blast percentage.

#AML #FLT3 #ITD #CSGE

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