Implications of Sex Hormone Receptor Gene Expression in the Predominance of Hepatocellular Carcinoma in Males: Role of Natural Products

Ahmed, Hanaa H; Shousha, Wafaa Gh; Shalby, Aziza B; El-Mezayen, Hatem A; Ismaiel, Nora N; Mahmoud, Nadia S

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자료유형: 학술저널

저자정보: Ahmed, Hanaa H (Hormones Department, Medical Research Division, National Research Centre) Shousha, Wafaa Gh (Chemistry Department, Faculty of Science, Helwan University) Shalby, Aziza B (Hormones Department, Medical Research Division, National Research Centre) El-Mezayen, Hatem A (Chemistry Department, Faculty of Science, Helwan University) Ismaiel, Nora N (Molecular Genetics and Enzymology Department, Human Genetics and Genome Research, National Research Centre) Mahmoud, Nadia S (Hormones Department, Medical Research Division, National Research Centre)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제12호

발행연도: 2015.1

수록면: 4,949 - 4,954 (6page)

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The present study was planned to investigate the role of sex hormone receptor gene expression in the pathogenesis of hepatocellular carcinoma (HCC). Adult male Wistar rats were divided into seven groups. Group (1) was negative control. Groups (2), (5), (6), and (7) were orally administered with N-nitrosodiethylamine for the induction of HCC, then group (2) was left untreated, group (5) was orally treated with curcumin, group (6) was orally treated with carvacrol, and group (7) was intraperitoneally injected with doxorubicin, whereas groups (3) and (4) were orally administered only curcumin and carvacrol, respectively. The HCC group showed significant upregulation in the androgen receptor (AR) and the estrogen receptor-alpha ($ER{\alpha}$) gene expression levels in the liver tissue. On the contrary, HCC groups treated with either curcumin or carvacrol showed significant downregulation in AR and $ER{\alpha}$ gene expression levels in the liver tissue. In conclusion, the obtained data highlight that both AR and $ER{\alpha}$ but not estrogen receptor-beta ($ER{\beta}$) gene expression may contribute to the male prevalence of HCC induced in male rats. Interestingly, both curcumin and carvacrol were found to have a promising potency in alleviating the male predominating HCC.

#Hepatocellular carcinoma #male #androgen receptor #estrogen receptor #curcumin #carvacrol

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