Assessment of Prognostic Value of Neutrophil to Lymphocyte Ratio and Prognostic Nutritional Index as a Sytemic Inflammatory Marker in Non-small Cell Lung Cancer

Kos, Fahriye Tugba; Hocazade, Cemil; Kos, Mehmet; Uncu, Dogan; Karakas, Esra; Dogan, Mutlu; Uncu, Hikmet Gulsen; Ozdemir, Nuriye; Zengin, Nurullah

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자료유형: 학술저널

저자정보: Kos, Fahriye Tugba (Department of Medical Oncology, Faculty of Medicine, Duzce University) Hocazade, Cemil (Department of Medical Oncology, Ankara Numune Education and Research Hospital) Kos, Mehmet (Department of Internal Medicine, Faculty of Medicine, Duzce University) Uncu, Dogan (Department of Medical Oncology, Ankara Numune Education and Research Hospital) Karakas, Esra (Department of Internal Medicine, Ankara Numune Education and Research Hospital) Dogan, Mutlu (Department of Medical Oncology, Ankara Numune Education and Research Hospital) Uncu, Hikmet Gulsen (Turkish Drug & Medical Device Institution) Ozdemir, Nuriye (Department of Medical Oncology, Ankara Numune Education and Research Hospital) Zengin, Nurullah (Department of Medical Oncology, Ankara Numune Education and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제9호

발행연도: 2015.1

수록면: 3,997 - 4,002 (6page)

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Background: Systemic inflammatory response was shown to play an important role in development and progression of many cancer types and different inflammation-based indices were used for determining prognosis. We aimed to investigate the prognostic effects of neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) in patients with non-small cell lung cancer (NSCLC). Materials and Methods: NSCLC patients diagnosed in our institution were retrospectively reviewed. Demographic and clinicopathologic characteristics were recorded. NLR and PNI was calculated before the application of any treatment. Results: A total of 138 patients were included in the study. Patients were divided into two groups according to NLR (<3.24 or ${\geq}3.24$) and PNI (<49.5 or ${\geq}49.5$). While median overall survival was 37.0 (95% CI 17.5-56.5) months in the group with low NLR, it was calculated as 10.0 (95%CI 5.0-15.0) months in the group with high NLR (p<0.0001). While median overall survival was 7.0 (95%CI 3.5-10.5) months in the group with low PNI, it was calculated as 33.0 (95% CI 15.5-50.4) months in the group with high PNI (p<0.0001). Stage, NLR and PNI levels were evaluated as independent risk factors for overall survival for all patients in multivariate analysis (p<0.0001, p=0.04 and p<0.001, respectively). Conclusions: NLR (${\geq}3.24$) and PNI (<49.5) at diagnosis is an independent marker of poor outcome in patients with NSCLC. NLR and PNI is an easily measured, reproducible prognostic tests that could be considered in NSCLC patients.

#Neutrophil #lymphocyte #prognostic nutritional index #lung cancer #prognosis

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