Multicenter Epidemiologic Study on Hepatocellular Carcinoma in Turkey

Can, Alper; Dogan, Erkan; Bayoglu, Ibrahim Vedat; Tatli, Ali Murat; Besiroglu, Mehmet; Kocer, Murat; Dulger, Ahmet Cumhur; Uyeturk, Ummugul; Kivrak, Derya; Orakci, Zuat; Bal, Oznur; Kacan, Turgut; Olmez, Sehmus; Turan, Nedim; Ozbay, Mehmet Fatih; Alacacioglu, Ahmet

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저자정보: Can, Alper (Department of Medical Oncology, Faculty of Medicine, Van Yuzuncu Yil University) Dogan, Erkan (Department of Medical Oncology, Faculty of Medicine, Van Yuzuncu Yil University) Bayoglu, Ibrahim Vedat (Department of Medical Oncology, Faculty of Medicine, Katip Celebi University) Tatli, Ali Murat (Department of Medical Oncology, Regional Training and Research Hospital) Besiroglu, Mehmet (Department of Medical Oncology, Faculty of Medicine Marmara University) Kocer, Murat (Department of Medical Oncology, Faculty of Medicine Sulayman Demirel University) Dulger, Ahmet Cumhur (Department of Medical Oncology, Faculty of Medicine, Van Yuzuncu Yil University) Uyeturk, Ummugul (Department of Medical Oncology, Faculty of Medicine, Izzet Baysal University) Kivrak, Derya (Department of Medical Oncology, Faculty of Medicine, Akdeniz University) Orakci, Zuat (Department of Medical Oncology, Faculty of Medicine Dicle University) Bal, Oznur (Department of Medical Oncology, Regional Training and Research Hospital) Kacan, Turgut (Department of Medical Oncology, Faculty of Medicine Cumhuriyet University) Olmez, Sehmus (Department of Medical Oncology, Faculty of Medicine, Van Yuzuncu Yil Uni) Turan, Nedim Ozbay, Mehmet Fatih Alacacioglu, Ahmet

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제6호

발행연도: 2014.1

수록면: 2,923 - 2,927 (5page)

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Background: Hepatocellular cancer (HCC) is one of the important health problems in Turkey, being very common and highly lethal. The aim of this study was to determine clinical, demographic features and risk factors. Materials and Methods: Nine hundred and sixth-three patients with HCC from 13 cities in Turkey were included in this study. Results: Only 205 (21%) of the 963 patients were women, with a male:female predominance of 4.8:1 and a median age of 61 years. The etiologic risk factors for HCC were hepatitis B in 555 patients (57.6%), 453 (81%) in men, and 102 (19%) in women, again with male predominance, hepatitis C in 159 (16.5%), (14.9% and 22.4%, with a higher incidence in women), and chronic alcohol abuse (more than ten years) in 137 (14.2%) (16.8% and 4.9%, higher in males). The Child-Pugh score paralleled with advanced disease stage amd also a high level of AFP. Conclusions: According to our findings the viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor. The Child-Pugh classification and AFP levels were determined to be important prognostic factors in HCC patients.

#Hepatocellular carcinoma #etiologic factors #alpha-fetoprotein #Turkey

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Can, Alper

소속기관 Department of Medical Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital