Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

Jeng, Jen-Eing; Wu, Hui-Fang; Tsai, Meng-Feng; Tsai, Huey-Ru; Chuang, Lea-Yea; Lin, Zu-Yau; Hsieh, Min-Yuh; Chen, Shinn-Chern; Chuang, Wan-Lung; Wang, Liang-Yen; Yu, Ming-Lung; Dai, Chia-Yen; Tsai, Jung-Fa

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자료유형: 학술저널

저자정보: Jeng, Jen-Eing (Department of Laboratory Medicine, Kaohsiung Medical University Hospital) Wu, Hui-Fang (Department of Pediatrics, Sinchu MaKay Memorial Hospital) Tsai, Meng-Feng (Department of Pediatrics, Sinchu MaKay Memorial Hospital) Tsai, Huey-Ru (Department of Internal Medicine, Madow Sin-Lau Hospital) Chuang, Lea-Yea (Department of Biochemistry, Kaohsiung Medical University) Lin, Zu-Yau (Division of Hepatobiliary, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University) Hsieh, Min-Yuh (Division of Hepatobiliary, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University) Chen, Shinn-Chern (Division of Hepatobiliary, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University) Chuang, Wan-Lung (Division of Hepatobiliary, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University) Wang, Liang-Yen (Division of Hepatobiliary, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University) Yu, Ming-Lung (Division of Hepatobiliary, Department of) Dai, Chia-Yen Tsai, Jung-Fa

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제23호

발행연도: 2014.1

수록면: 10,209 - 10,215 (7page)

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To assess the contribution of tumor necrosis factor $(TNF){\beta}$ +252 polymorphisms to risk and prognosis of hepatocellular carcinoma (HCC), we enrolled 150 pairs of sex- and age-matched patients with HCC, patients with cirrhosis alone, and unrelated healthy controls. $TNF{\beta}$ +252 genotypes were determined by polymerase chain reaction with restriction fragment length polymorphism. Multivariate analysis indicated that $TNF{\beta}$ G/G genotype [odds ratio (OR), 3.64; 95%CI, 1.49-8.91], hepatitis B surface antigen (OR, 16.38; 95%CI, 8.30-32.33), and antibodies to hepatitis C virus (HCV) (OR, 39.11; 95%CI, 14.83-103.14) were independent risk factors for HCC. There was an additive interaction between $TNF{\beta}$ G/G genotype and chronic hepatitis B virus (HBV)/HCV infection (synergy index=1.15). Multivariate analysis indicated that factors associated with $TNF{\beta}$ G/G genotype included cirrhosis with Child-Pugh C (OR, 4.06; 95%CI, 1.34-12.29), thrombocytopenia (OR, 6.55; 95%CI, 1.46-29.43), and higher serum ${\alpha}$-fetoprotein concentration (OR, 2.53; 95%CI, 1.14-5.62). Patients with $TNF{\beta}$ G/G genotype had poor cumulative survival (p=0.005). Cox proportional hazard model indicated that $TNF{\beta}$ G/G genotype was a biomarker for poor HCC survival (hazard ratio, 1.70; 95%CI, 1.07-2.69). In conclusion, there are independent and additive effects between $TNF{\beta}$ G/G genotype and chronic HBV/HCV infection on risk for HCC. It is a biomarker for poor HCC survival. Carriage of this genotype correlates with disease severity and advanced hepatic fibrosis, which may contribute to a higher risk and poor survival of HCC. Chronic HBV/HCV infected subjects with this genotype should receive more intensive surveillance for early detection of HCC.

#Tumor necrosis factor ${beta}$ polymorphism #hepatocellular carcinoma #susceptibility #prognosis

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