Microstructure and Biocompatibility of Porous BCP(HA/β-TCP) Biomaterials Consolidated by SPS Using Space Holder

Woo, Kee-Do; Kwak, Seung-Mi; Lee, Tack; Oh, Seong-Tak; Woo, Jeong-Nam

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자료유형: 학술저널

저자정보: Woo, Kee-Do (Division of Advanced Material Engineering & RCAMD, Chonbuk National University) Kwak, Seung-Mi (Division of Advanced Material Engineering & RCAMD, Chonbuk National University) Lee, Tack (Division of Advanced Material Engineering & RCAMD, Chonbuk National University) Oh, Seong-Tak (Division of Advanced Material Engineering & RCAMD, Chonbuk National University) Woo, Jeong-Nam (College of Veterinary Medicine, Chonbuk National University, National Institute of Food and Drug Safety Evaluation)

저널정보: 한국재료학회 한국재료학회지 한국재료학회지 제26권 제8호

발행연도: 2016.1

수록면: 449 - 453 (5page)

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연구결과

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$HA(hydroxyapatite)/{\beta}-TCP$ (tricalcium phosphate) biomaterial (BCP; biphasic calcium phosphate) is widely used as bone cement or scaffolds material due to its superior biocompatibility. Furthermore, $NH_4HCO_3$ as a space holder (SH) has been used to evaluate feasibility assessment of porous structured BCP as bone scaffolds. In this study, using a spark plasma sintering (SPS) process at 393K and 1373K under 20MPa load, porous $HA/{\beta}-TCP$ biomaterials were successfully fabricated using $HA/{\beta}-TCP$ powders with 10~30 wt% SH, TiH2 as a foaming agent, and MgO powder as a binder. The effect of SH content on the pore size and distribution of the BCP biomaterial was observed by scanning electron microscopy (SEM) and a microfocus X-ray computer tomography system (SMX-225CT). The microstructure observations revealed that the volume fraction of the pores increased with increasing SH content and that rough pores were successfully fabricated by adding SH. Accordingly, the cell viabilities of BCP biomaterials were improved with increasing SH content. And, good biological properties were shown after assessment using Hanks balanced salt solution (HBSS).

#porous bioceramics #hydroxyapatite #tricalcium phosphate #biphasic calcium phosphate #space holder

참고문헌 (20)

참고문헌 신청

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S. H. Ahn / 1996 / Proceedings of the 46th ECTC :107

S. Kang / 1997 / J. Electron. Mater 26:805

S. Hyun / 2003 / Appl. Phys. Lett 83:4411

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