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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Brown algal extracts have long been used as feed supplements to promote health of farm animals. Here, we show new molecular insights in to the mechanism of action of a fucose containing polymer (FCP) rich fraction from the brown seaweed Ascophyllum nodosum using the Caenorhabditis elegans-Pseudomonas aeruginosa PA14 infection model. FCP enhanced survival of C. elegans against pathogen stress, correlated with up-regulation of key immune response genes such as: lipases, lysozyme (lys-1), saponin-like protein (spp-1), thaumatin-like protein (tlp-1), matridin SK domain protein (msk-1), antibacterial protein (abf-1), and lectin family protein (lfp). Further, FCP caused down regulation of P. aeruginosa quorum sensing genes: (lasI, lasR, rhlI, and rhlR), secreted virulence factors (lipase, proteases, and elastases) and toxic metabolites (pyocyanin, hydrogen cyanide, and siderophore). Biofilm formation and motility of pathogenic bacteria were also greatly attenuated when the culture media were treated with FCP. Interestingly, FCP failed to mitigate the pathogen stress in skn-1, daf-2, and pmk-1 mutants of C. elegans. This indicated that, FCP treatment acted on the regulation of fundamental innate immune pathways, which are conserved across the majority of organisms including humans. This study suggests the possible use of FCP, a seaweed component, as a functional food source for healthy living.
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참고문헌 (38)
참고문헌 신청
Aballay, A / 2002 / Caenorhabditis elegans as a host for the study of host-pathogen interactions / Curr. Opin. Microbiol 5:97~101
Alekseyenko, T. V / 2007 / Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga / Bull. Exp. Biol. Med 143:730~732
Allen, V. G / 2001 / Tasco: influence of a brown seaweed on antioxidants in forages and livestock-a review / J. Anim. Sci 79:E21~E31
Anastyuk, S. D / 2012 / Anticancer activity in vitro of a fucoidan from the brown alga Fucus evanescens and its low-molecular fragments, structurally characterized by tandem mass-spectrometry / Carbohydr. Polym 87:186~194
Bilan, M. I / 2006 / Structure of a fucoidan from the brown seaweed Fucus serratus L / Carbohydr. Res 341:238~245
Alekseyenko, T. V / 2007 / Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga / Bull. Exp. Biol. Med 143:730~732
Allen, V. G / 2001 / Tasco: influence of a brown seaweed on antioxidants in forages and livestock-a review / J. Anim. Sci 79:E21~E31
Anastyuk, S. D / 2012 / Anticancer activity in vitro of a fucoidan from the brown alga Fucus evanescens and its low-molecular fragments, structurally characterized by tandem mass-spectrometry / Carbohydr. Polym 87:186~194
Bilan, M. I / 2006 / Structure of a fucoidan from the brown seaweed Fucus serratus L / Carbohydr. Res 341:238~245
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