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논문 기본 정보

자료유형
학술저널
저자정보
Park, Seul-Ki (Department of Medical Biotechnology, SoonChunHyang University) Kim, Yoon-Kyung (Department of Medical Biotechnology, SoonChunHyang University) Youn, Hyung-Sun (Department of Biomedical Laboratory Science, SoonChunHyang University) Lee, Mi-Young (Department of Medical Biotechnology, SoonChunHyang University)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제4권 제1호
발행연도
2008.1
수록면
52 - 60 (9page)

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In order to investigate whether the particles reduced to almost nano grade might affect the chemical and physical properties of organic materials, whole Korean Black-Red Ginseng was pulverized into almost nano size and then ginsenosides, minerals, carbohydrates, lipids and proteins in the ultrafine particles were compared with those in the regular particles as control. The mean size of the ultrafine particles was in the 350 nm range, while that of the regular particles was $127{\mu}m$. More ginsenosides, minerals, carbohydrates, lipids and proteins were detected in the ultrafine particles than in the regular particles. Interestingly, more lipids from the ultrafine particles dissolved in the water than those from the regular particles in the ethanol. Absorption and transport of carbohydrate, lipid or antioxidant activity across the intestinal wall using everted intestine sacks of mice was also enhanced by particle size reduction at the almost nano scale. More cytotoxic effect against hepatoma cell growth by ultrafine particles was also found. These results could be used as the basic data for the understanding and evaluation of the effects of organic nanomaterials on the human health.

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