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자료유형
학술저널
저자정보
Kim, Yu-Ri (Department of Biochemistry & Molecular Biology, Korea University College of Medicine) Kim, In-Kyoung (Department of Biochemistry & Molecular Biology, Korea University College of Medicine) Seo, Sang-Hui (Department of Biochemistry & Molecular Biology, Korea University College of Medicine) Lee, Seung-Ho (Department of Biochemistry & Molecular Biology, Korea University College of Medicine) Lee, Hee-Ra (Department of Biochemistry & Molecular Biology, Korea University College of Medicine) Pie, Jae-Eun (Department of Food and Nutrition, College of Science and Engineering, Anyang University) Kim, Meyoung-Kon (Department of Biochemistry & Molecular Biology, Korea University College of Medicine)
저널정보
대한독성유전단백체학회 Molecular & cellular toxicology Molecular & cellular toxicology 제6권 제4호
발행연도
2010.1
수록면
345 - 351 (7page)

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The increasing prevalence and severity of environmental diseases have been attributed the rise in environmental pollutants occurring as a consequence of industrial development. In this study, we examined that underlying mechanisms of toluene in human lung epithelial cells. We selected two genes known to be involved in environmental disease such as RANTES and eotaxin for the present study based on published reports and prior observation. We observed that toluene increased the mRNA and protein levels of RANTES and eotaxin in a dose-dependent manner, together with the activation of p38 MAPK and JNK. Moreover, the inhibition of p38 MAPK and JNK activation prevented the release of RANTES and eotaxin induced by toluene. The present study is the first to show that toluene exposure induces the expression of RANTES and eotaxin in human bronchial epithelial cells through two distinct MAPKs such as p38 and JNK. Our observations suggest that modulation of the expression of immunerelated chemokines and cytokines may be important factors in development of environmental diseases induced by air pollutants.

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