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논문 기본 정보

자료유형
학술저널
저자정보
Cho, Hun-Bum (Department of Herbology, College of Oriental Medicine, Daegu Haany University) Park, Ji-Ha (Department of Herbology, College of Oriental Medicine, Daegu Haany University) Seo, Bu-Il (Department of Herbology, College of Oriental Medicine, Daegu Haany University) Cho, Su-Yeon (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University) Park, Kyu-Ryul (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University) Choi, Seung-Hoon (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University) Han, Chang-Kyun (Department of Oriental Medicinal Materials & Processing, College of Life Science, Kyung Hee University) Song, Chang-Hyun (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University) Park, Soo-Jin (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University) Ku, Sae-Kwang (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University)
저널정보
대한본초학회 대한본초학회지(본초분과학회지) 대한본초학회지 제28권 제3호
발행연도
2013.1
수록면
17 - 24 (8page)

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Objectives : This study was to evaluate the single dose toxicity of Persicae Semen (PS) in ICR mice. Methods : Aqueous extracts of PS (Yield = 18.60%) were administered as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) guidelines (2009-116, 2009). Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 12 principle organs were examined. Results : Amygdalin contents in PS aqueous extracts were detected as $32.50{\pm}5.96{\mu}g/ml$. We could not find any PS extracts treatment related mortalities, clinical signs, changes on the body and organ weights, gross and histopathological observations up to 2,000 mg/kg in both female and male mice, except for transient and slight loss of locomotion detected in female and male mice treated with 2,000 mg/kg. In addition, pharmacological immunomodulatory effects related findings were also demonstrated in 2,000mg/kg treated female and male mice as hypertrophy and hyperplasia of lymphoid cells in the submandibular lymph nodes. Conclusions : Based on the results of this experiment, the approximate lethal dose (ALD) of PS extracts after single oral treatment in female and male mice were considered above 2,000 mg/kg, respectively. It should be carefully used in clinics because the possibilities of respiratory or neurological disorders were observed when administered over 2,000 mg/kg of PS extract related to amygdalin.
#Persicae Semen #Single oral dose toxicity #Mouse #Amygdalin #Histopathology

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참고문헌 (25)

참고문헌 신청
Devipriya N / 2007 / Effect of ellagic acid, a natural polyphenol, on alcohol-induced prooxidant and antioxidant imbalance: a drug dose dependent study / Singapore Med J 48(4):311~318 google schola Noh JR / 2011 / Hepatoprotective effect of Platycodon grandiflorum against chronic ethanol-induced oxidative stress in C57BL/6 mice / Ann Nutr Metab 58(3):224~231 google schola 노성수 / 2010 / Mouse Single Oral Dose Toxicity Study of DHU001, a Polyherbal Formula / 한국독성학회지 26(1):53~59 google schola 서부일 / 2011 / 益母草와 桃仁이 임신 흰쥐에 미치는 영향 / 대한본초학회지 26(1):47~52 google schola Wang N / 2002 / Experimental study on anti-thrombus effect of different extracts from Semen Persicae / Zhong Yao Cai 25:414~415 google schola

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