Clinical Outcomes of Diffuse Axonal Injury According to Radiological Grade

Lee, Hak-Jae; Sun, Hyun-Woo; Lee, Jae-Seok; Choi, Nak-Joon; Jung, Yoon-Joong; Hong, Suk-Kyung

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자료유형: 학술저널

저자정보: Lee, Hak-Jae (Division of Acute Care Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) Sun, Hyun-Woo (Division of Acute Care Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) Lee, Jae-Seok (Division of Acute Care Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) Choi, Nak-Joon (Division of Acute Care Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) Jung, Yoon-Joong (Division of Acute Care Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) Hong, Suk-Kyung (Division of Acute Care Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine)

저널정보: 대한외상학회 Journal of trauma and injury : JTI Journal of trauma and injury : JTI 제31권 제2호

발행연도: 2018.1

수록면: 51 - 57 (7page)

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Purpose: Patients with diffuse axonal injury experience various disabilities and have a high cost of treatment. Recent researches have revealed the underlying mechanism and pathogenesis of diffuse axonal injury. This study aimed to investigate the correlation between the radiological grading of diffuse axonal injury and the clinical outcomes of patients. Methods: From January 2011 to December 2016, among 294 patients with traumatic brain injury, 44 patients underwent magnetic resonance imaging (MRI). A total of 18 patients were enrolled in this study except for other cerebral injuries, such as cerebral hemorrhage or hypoxic brain damage. Demographic data, clinical data, and radiological findings were retrospectively reviewed. The grading of diffuse axonal injury was analyzed based on patient's MRI findings. Results: For the most severe diffuse axonal injury patients, prolonged intensive care unit (ICU) stay (p=0.035), hospital stay (p=0.012), and prolonged mechanical ventilation (p=0.030) were observed. However, there was no significant difference in healthcare-associated infection rates between MRI grading (p=0.123). Massive transfusion, initial hemoglobin and lactate levels, and MRI gradings were found to be highly significant in predicting the duration of unconsciousness. Conclusions: This study showed that patients with high grade diffuse axonal injury have prolonged ICU stays and significantly longer hospital stays. Deteriorated mental patients with high energy injuries should be evaluated to identify diffuse axonal injuries by using an appropriate imaging tool, such as MRI. It will be important to predict the duration of consciousness recovery using MRI scans.

#Brain injury, Traumatic #Diffuse axonal injury #Magnetic resonance imaging #Prognosis

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Lee, Hak-Jae

소속기관 Division of Acute Care Surgery, Department of Surgery, Asan Medical Center, University of Ulsan Coll