지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 101 - 109 (9page)
이용수
초록· 키워드
오류제보하기
Objectives : HT070 is a mixture of herbal extracts from root of Scutellaria baicalensis and stem bark of Eleutherococcus senticosus , which have long been used for stroke therapy in traditional Korean Medicine. The purpose of this study was to investigate the neuroprotective effects of HT070 on global cerebral ischemia and its potential mechanisms.Methods : Transient global cerebral ischemia was produced by 10 min of four-vessel occlusion (4-VO) in male Wistar rats. HT070 was administered orally at a dosage of 200 mg/kg twice at 0 and 90 min after reperfusion. Hippocampal neuronal damage was measured 7 days after reperfusion. To explore the potential mechanisms, we used hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced rat pheochromocytoma (PC12) cells as an in vitro model. PC12 cells were pretreated with HT070 for 1 h and then exposed to 100 μM H<sub>2</sub>O<sub>2</sub> for 6 h in the presence of HT070. Cell viability was measured by MTT assay and the mRNA expression of Bax, Bcl-2, iNOS and COX-2 were measured by quantitative RT-PCR.Results : Oral administration of HT070 at a dose of 200 mg/kg significantly reduced neuronal death in the hippocampal CA1 region by 13.4% as compared to the vehicle-treated group. HT070 increased cell viability, reversed the down-regulated Bcl-2 mRNA level, and suppressed the up-regulated mRNA expressions of Bax, iNOS, and COX-2 in H<sub>2</sub>O<sub>2</sub>-treated PC12 cells.Conclusions : HT070 protects against delayed neuronal death after global cerebral ischemia and its neuroprotection properties might be attributed to the inhibition of mitochondrial apoptosis and ROS-generating enzymes.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Zola-Morgan S / 1986 / Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus / J Neurosci 6(10):2950~2967
Lim C / 2004 / The neurological and cognitive sequelae of cardiac arrest / Neurology 63(10):1774~1778
Woodruff TM / 2011 / Pathophysiology, treatment, and animal and cellular models of human ischemic stroke / Mol Neurodegener 6(1):11
Majid A / 2014 / Neuroprotection in stroke: past, present, and future / ISRN Neurol 2014:515716
Onwuekwe I / 2012 / Ischemic stroke and neuroprotection / Ann Med Health Sci Res 2(2):186~190
Lim C / 2004 / The neurological and cognitive sequelae of cardiac arrest / Neurology 63(10):1774~1778
Woodruff TM / 2011 / Pathophysiology, treatment, and animal and cellular models of human ischemic stroke / Mol Neurodegener 6(1):11
Majid A / 2014 / Neuroprotection in stroke: past, present, and future / ISRN Neurol 2014:515716
Onwuekwe I / 2012 / Ischemic stroke and neuroprotection / Ann Med Health Sci Res 2(2):186~190
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effectiveness range and persistence of transcranial direct current stimulation against neuronal death by the transient cerebral ischemia
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Neuroprotective effect of epigallocatechin gallate against MCAO-induced focal cerebral ischemia
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Neuroprotective effect of chlorogenic acid in cerebral cortex of stroke animal model
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Quercetin protects neuronal cells against focal cerebral ischemia and glutamate-induced damage via inhibition of apoptotic pathway
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Identification of regulated proteins by EGCG in cerebral cortex of middle cerebral artery occlusion animal model
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Quercetin alleviated decrease of thioredoxin expression in focal cerebral ischemia and glutamate-induced neuronal cells damage
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Altered Nurr1 protein expression in the hippocampal CA1 region following transient global cerebral ischemia
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Relationship between ischemic preconditioninginduced neuroprotection and antioxidants enzymes expressions in the gerbil hippocampal CA1 region following a subsequent lethal transient cerebral ischemia
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Effect of acupuncture on short-term memory and apoptosis after transient cerebral ischemia in gerbils
대한한의학회지
2018 .12
-
Neuroprotective Effect of Chronic Intracranial Toxoplasma gondii Infection in a Mouse Cerebral Ischemia Model
Parasites, Hosts and Diseases
2020 .08
-
Fucoidan-mediated antioxidant properties attenuate acceleration and exacerbation of transient global cerebral ischemia-induced neuronal death in the hippocampus of high-fat diet-induced obese gerbils
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Quercetin reduces the injury-induced reduction of γ-enolase expression in a middle cerebral artery occlusion animal model
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Pretreated Korean red pine bark extract provides potent neuroprotection against transient global cerebral ischemic injury in the gerbil hippocampus through its antioxidant action
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Pretreated duloxetine protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury through decrease of oxidative stress
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats
대한신경외과학회지
2015 .01
-
Neuroprotective potential of imatinib in global ischemiareperfusion- induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
The Korean Journal of Physiology & Pharmacology
2020 .01
-
Time interval after ischemic preconditioning affects neuroprotection and gliosis in the gerbil hippocampal CA1 region induced by transient cerebral ischemia
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Rufinamide pretreatment attenuates ischemia-reperfusion injury in the gerbil hippocampus
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling
PSYCHIATRY INVESTIGATION
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0