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논문 기본 정보

자료유형
학술저널
저자정보
Rim, Kyung-Taek (Chemicals Safety and Health Center, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) Kim, Soo-Jin (Chemicals Safety and Health Center, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
저널정보
산업안전보건연구원 Safety and health at work : SH@W Safety and health at work : SH@W 제6권 제3호
발행연도
2015.1
수록면
184 - 191 (8page)

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Chemical mutagenicity is a major hazard that is important to workers' health. Despite the use of large amounts of allyl chloride, the available mutagenicity data for this chemical remains controversial. To clarify the mutagenicity of allyl chloride and because a micronucleus (MN) test had not yet been conducted, we screened for MN induction by using male ICR mice bone marrow cells. The test results indicated that this chemical is not mutagenic under the test conditions. In this paper, the regulatory test battery and several assay combinations used to determine the genotoxic potential of chemicals in the workplace have been described. Further application of these assays may prove useful in future development strategies of hazard evaluations of industrial chemicals. This study also should help to improve the testing of this chemical by commonly used mutagenicity testing methods and investigations on the underlying mechanisms and could be applicable for workers' health.

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