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논문 기본 정보

자료유형
학술저널
저자정보
Kwon, Oran (Ewha Brain Institute, Ewha Womans University) Lee, Sunho (Ewha Brain Institute, Ewha Womans University) Ban, Soonhyun (Ewha Brain Institute, Ewha Womans University) Im, Jooyeon J. (Ewha Brain Institute, Ewha Womans University) Lee, Doo Suk (School of Biological Sciences, Seoul National University) Lee, Eun Hee (Green Cross Laboratories) Kim, Joohee (Department of Nutritional Science and Food Management, College of Health Sciences, Ewha Womans University) Lim, Soo Mee (Ewha Brain Institute, Ewha Womans University) Lee, Sang Gon (Green Cross Laboratories) Kang, Ilhyang (Ewha Brain Institute, Ewha Womans University) Kim, Kyung-Hee (Division of Cardiology, Department of Internal Medicine, Sejong General Hospital) Yoon, Sujung (Ewha Brain Institute, Ewha Womans University) Lee, Sun Hea (Ewha Brain Institute, Ewha Womans University)
저널정보
대한생물정신의학회 생물정신의학 생물정신의학 제22권 제2호
발행연도
2015.1
수록면
63 - 77 (15page)

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Objectives The combination extract of four kinds of herbs, Gastrodia elata, Liriope platyphylla, Dimocarpus longan, and Salvia miltiorrhiza, has shown to have memory improving effects in mice. The aim of this study was to investigate the efficacy and safety of the herbal mixture for improving working memory as well as microstructural changes in white matter integrity in individuals with subjective memory complaints. Methods Seventy-five individuals with subjective memory complaints were assigned to receive either placebo (n = 15) or herbal mixture (low-dose group, n = 30 and high-dose group, n = 30) supplementation in an 8-week, randomized, double-blind, placebo-controlled clinical trial. Changes in working memory performance and fractional anisotropy (FA) values reflecting white matter integrity from baseline to 8-week endpoint were assessed. Results The herbal mixture group showed an increase in working memory performance compared to the placebo group (p for interaction = 0.001). In addition, the herbal mixture group showed an increase in FA values in the temporo-parietal regions (corrected p < 0.05), which are crucially involved in working memory function and are among the most affected regions in patients with cognitive impairments. Conclusions Findings from this study indicate that the herbal mixture may be a promising therapeutic option for individuals with subjective memory complaints.

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