지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 472 - 479 (8page)
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초록· 키워드
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Background Speech problems are a common clinical feature of the 22q11.2 deletion syndrome. The objectives of this study were to inventory the speech history and current self-reported speech rating of adolescents and young adults, and examine the possible variables influencing the current speech ratings, including cleft palate, surgery, speech and language therapy, intelligence quotient, and age at assessment. Methods In this cross-sectional cohort study, 50 adolescents and young adults with the 22q11.2 deletion syndrome (ages, 12-26 years, 67% female) filled out questionnaires. A neuropsychologist administered an age-appropriate intelligence quotient test. The demographics, histories, and intelligence of patients with normal speech (speech rating=1) were compared to those of patients with different speech (speech rating>1). Results Of the 50 patients, a minority (26%) had a cleft palate, nearly half (46%) underwent a pharyngoplasty, and all (100%) had speech and language therapy. Poorer speech ratings were correlated with more years of speech and language therapy (Spearman's correlation=0.418, P=0.004; 95% confidence interval, 0.145-0.632). Only 34% had normal speech ratings. The groups with normal and different speech were not significantly different with respect to the demographic variables; a history of cleft palate, surgery, or speech and language therapy; and the intelligence quotient. Conclusions All adolescents and young adults with the 22q11.2 deletion syndrome had undergone speech and language therapy, and nearly half of them underwent pharyngoplasty. Only 34% attained normal speech ratings. Those with poorer speech ratings had speech and language therapy for more years.
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참고문헌 (25)
참고문헌 신청
McDonald-McGinn DM / 2011 / Chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome) / Medicine (Baltimore) 90:1~18
Spruijt NE / 2012 / In search of the optimal surgical treatment for velopharyngeal dysfunction in 22q11.2 deletion syndrome: a systematic review / PLoS One 7:e34332.
D’Antonio LL / 2001 / Analysis of speech characteristics in children with velocardiofacial syn-drome (VCFS) and children with phenotypic overlap with-out VCFS / Cleft Palate Craniofac J 38:455~467
Persson C / 2003 / A prospective cross-sectional study of speech in patients with the 22q11deletion syndrome / J Commun Disord 36:13~47
Widdershoven JC / 2008 / Possible mechanisms and gene involvement in speech problems in the 22q11.2 deletion syndrome / J Plast Reconstr Aesthet Surg 61:1016~1023
Spruijt NE / 2012 / In search of the optimal surgical treatment for velopharyngeal dysfunction in 22q11.2 deletion syndrome: a systematic review / PLoS One 7:e34332.
D’Antonio LL / 2001 / Analysis of speech characteristics in children with velocardiofacial syn-drome (VCFS) and children with phenotypic overlap with-out VCFS / Cleft Palate Craniofac J 38:455~467
Persson C / 2003 / A prospective cross-sectional study of speech in patients with the 22q11deletion syndrome / J Commun Disord 36:13~47
Widdershoven JC / 2008 / Possible mechanisms and gene involvement in speech problems in the 22q11.2 deletion syndrome / J Plast Reconstr Aesthet Surg 61:1016~1023
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