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논문 기본 정보

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학술저널
저자정보
Cai, Elijah Zhengyang (Department of Surgery, National University Health System) Ang, Chuan Han (Department of Surgery, Yong Loo Lin School of Medicine, Natioanl University of Singapore) Raju, Ashvin (Department of Surgery, Yong Loo Lin School of Medicine, Natioanl University of Singapore) Tan, Kong Bing (Department of Surgery, Yong Loo Lin School of Medicine, Natioanl University of Singapore) Hing, Eileen Chor Hoong (Department of Surgery, Yong Loo Lin School of Medicine, Natioanl University of Singapore) Loo, Yihua (Institute of Bioengineering and Nanotechnology, Agency of Science, Technology and Research) Wong, Yong Chiat (Defence Medical and Environmental Research Institute, DSO National Laboratories) Lee, Hanjing (Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, National University Health System) Lim, Jane (Department of Surgery, Yong Loo Lin School of Medicine, Natioanl University of Singapore) Moochhala, Shabbir M. (Defence Medical and Environmental Research Institute, DSO National Laboratories) Hauser, Charlotte A.E. (Institute of Bioengineering and Nanotechnology, Agency of Science, Technology and Research) Lim, Thiam Chye (Department of Surg)
저널정보
대한성형외과학회 Archives of plastic surgery : APS Archives of plastic surgery : APS 제41권 제4호
발행연도
2014.1
수록면
317 - 324 (8page)

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Background Burn infliction techniques are poorly described in rat models. An accurate study can only be achieved with wounds that are uniform in size and depth. We describe a simple reproducible method for creating consistent burn wounds in rats. Methods Ten male Sprague-Dawley rats were anesthetized and dorsum shaved. A 100 g cylindrical stainless-steel rod (1 cm diameter) was heated to $100^{\circ}C$ in boiling water. Temperature was monitored using a thermocouple. We performed two consecutive toe-pinch tests on different limbs to assess the depth of sedation. Burn infliction was limited to the loin. The skin was pulled upwards, away from the underlying viscera, creating a flat surface. The rod rested on its own weight for 5, 10, and 20 seconds at three different sites on each rat. Wounds were evaluated for size, morphology and depth. Results Average wound size was $0.9957cm^2$ (standard deviation [SD] 0.1845) (n=30). Wounds created with duration of 5 seconds were pale, with an indistinct margin of erythema. Wounds of 10 and 20 seconds were well-defined, uniformly brown with a rim of erythema. Average depths of tissue damage were 1.30 mm (SD 0.424), 2.35 mm (SD 0.071), and 2.60 mm (SD 0.283) for duration of 5, 10, 20 seconds respectively. Burn duration of 5 seconds resulted in full-thickness damage. Burn duration of 10 seconds and 20 seconds resulted in full-thickness damage, involving subjacent skeletal muscle. Conclusions This is a simple reproducible method for creating burn wounds consistent in size and depth in a rat burn model.
#Animals #Burns #Rats wound healing

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참고문헌 (20)

참고문헌 신청
Pessolato AG / 2011 / Propolis and amnion reepithelialise second-degree burns in rats / Burns 37:1192~1201 google schola Gurung S / 2009 / Wound healing properties of Carica papaya latex: in vivo evaluation in mice burn model / J Ethnopharmacol 121:338~341 google schola Priya KS / 2002 / Healing potential of Datura alba on burn wounds in albino rats / J Ethnopharmacol 83:193~199 google schola Eloy R / 1992 / Wound healing of burns in rats treated with a new amino acid copolymer membrane / Burns 18:405~411 google schola Upadhyay NK / 2009 / Safety and heal-ing efficacy of Sea buckthorn (Hippophae rhamnoides L.)seed oil on burn wounds in rats / Food Chem Toxicol 47:1146~1153 google schola

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