개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 뮤코다당증연구학회 Journal of mucopolysaccharidosis and rare disease Journal of mucopolysaccharidosis and rare disease 제2권 제2호
- 발행연도
- 2016.1
- 수록면
- 35 - 37 (3page)
이용수
초록· 키워드
오류제보하기
Prader-Willi syndrome (PWS) often develops type 2 diabetes mellitus (T2DM) related to severe obesity. The prevalence of T2DM in adults with PWS (7-20%) exceeds greatly the prevalence in the general population (5-7%). It is uncommon for pre-pubertal children with PWS to develop overt diabetes or glucose intolerance. GH therapy and genotype did not influence the development of altered glucose metabolism. It has been assumed that T2DM in PWS develops as a consequence of morbid obesity and concomitant insulin resistance. However recent studies suggest the relationship between morbid obesity and T2DM development is more complex and appears to differ in PWS subjects compared to non-PWS subjects. PWS patients had relatively lower fasting insulin levels and increased adiponectin levels compared with BMI-matched obese control despite of similar levels of leptin. So PWS children may be protected to some extent form of obesity-associated insulin resistance. Although there's no data, it seems logical to approach diabetes management including weight loss and increased exercise, using similar pharmacological agents as with non-PWS obesity-related diabetes such as metformin or thiazolidinedione, with the introduction of insulin as required. On the other hand, several recent T2DM in PWS case reports suggest favorable outcomes using Glucagon-like peptide 1 (GLP-1) analog with regard to ghrelin reduction, control of glucose and appetite, weight loss and pre-prandial insulin secretion. The role of GLP-1 agonist therapy is promising, but has not yet been fully elucidated.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Prader-Willi syndrome: an update on obesity and endocrine problems
Annals of Pediatirc Endocrinology & Metabolism
2021 .12
-
Issues in Adults Prader-Willi Syndrome
Journal of mucopolysaccharidosis and rare disease
2015 .01
-
Obesity and Metabolic Syndrome in Adults with Prader-Willi Syndrome
Journal of mucopolysaccharidosis and rare disease
2015 .01
-
Evaluating the Efficacy of Pharmacological Therapy for Prader-Willi Syndrome: A Systematic Review and Meta-analysis
한국임상약학회지
2022 .12
-
Introduction to the New Version of PWS Application and It's Use in Medical Practice
Journal of mucopolysaccharidosis and rare disease
2016 .01
-
Successful rapid weight reduction and the use of liraglutide for morbid obesity in adolescent Prader-Willi syndrome
Annals of Pediatirc Endocrinology & Metabolism
2020 .01
-
Growth Hormone Therapy in Adults with Prader-Willi Syndrome
Journal of mucopolysaccharidosis and rare disease
2015 .01
-
Genetics of Prader-Willi syndrome and Prader-Will-Like syndrome
Annals of Pediatirc Endocrinology & Metabolism
2016 .01
-
An 18-year-old patient with Prader-Willi syndrome: a case report on dental management under sedation and general anesthesia
Journal of dental anesthesia and pain medicine
2015 .01
-
프래더-윌리 증후군을 가진 46개월 소아의 치과치료 : 증례보고
International Journal of Disability and Oral Health
2019 .06
-
Birth seasonality in Korean Prader-Willi syndrome with chromosome 15 microdeletion
Annals of Pediatirc Endocrinology & Metabolism
2015 .01
-
Growth Hormone Therapy in PWS with Mobile Application-Living with PWS
Journal of mucopolysaccharidosis and rare disease
2018 .01
-
Gene Expression Related to Cognitive Function in Growth Hormone-treated Mice with Prader-Willi Syndrome
Journal of mucopolysaccharidosis and rare disease
2016 .01
-
Clinical Usefulness of Aripiprazole Treatment in a Girl with Prader-Willi Syndrome and Psychosis
Clinical Psychopharmacology and Neuroscience
2018 .01
-
Challenges of Growth Hormone Therapy in PWS during Transition
Journal of mucopolysaccharidosis and rare disease
2017 .01
-
Tailored management of life-threatening complications related to severe obesity in a young adult with Prader-Willi syndrome
Annals of Pediatirc Endocrinology & Metabolism
2022 .06
-
소아 허약 검사의 개발과 타당화 연구
대한한방소아과학회지
2019 .01
-
Insulin/GLP-1 Treatment for Patients with DM
Journal of mucopolysaccharidosis and rare disease
2016 .01
-
Quality of Life in Prader-Willi Syndrome Patients
Journal of mucopolysaccharidosis and rare disease
2015 .01
-
Beneficial Effects of Growth Hormone Treatment in Prader-Willi Syndrome
Journal of mucopolysaccharidosis and rare disease
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0