지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 뮤코다당증연구학회 Journal of mucopolysaccharidosis and rare disease Journal of mucopolysaccharidosis and rare disease 제2권 제2호
- 발행연도
- 2016.1
- 수록면
- 46 - 49 (4page)
이용수
초록· 키워드
오류제보하기
Achondroplasia is autosomal dominant genetic disease and fibroblast growth factor receptor 3 (FGFR3) is currently known to be the only gene that causes achondroplasia. Gain-of function mutation in fibroblast-growth-factor-receptor 3 (FGFR3) causes the disease and C-type natriuretic peptide (CNP) antagonizes FGFR3 downstream signaling by inhibiting the pathway of mitogen-activated protein kinase (MAPK). As FGFR3-related skeletal dysplasias are caused by growth attenuation of the cartilage, chondrocytes appear to be unique in their response to FGFR3 activation. However, the full spectrum of molecular events by which FGFR3 mediates its signaling is just beginning to emerge. This article summaries the mechanisms of FGFR3 function in skeletal dysplasias, the extraordinary cellular manifestations of FGFR3 signaling in chondrocytes, and finally, the progress toward therapy for ACH.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Fibroblast Growth Factor Receptor 1 Overexpression Is Associated with Poor Survival in Patients with Resected Muscle Invasive Urothelial Carcinoma
Yonsei Medical Journal
2016 .01
-
Fibroblast Growth Factor Receptor 1 (FGFR1) Amplification Detected by Droplet Digital Polymerase Chain Reaction (ddPCR) Is a Prognostic Factor in Colorectal Cancers
Cancer Research and Treatment
2020 .01
-
Fibroblast growth factor receptor isotype expression and its association with overall survival in patients with hepatocellular carcinoma
Clinical and Molecular Hepatology
2015 .01
-
FGFR4 Gly388Arg Polymorphism Affects the Progression of Gastric Cancer by Activating STAT3 Pathway to Induce Epithelial to Mesenchymal Transition
Cancer Research and Treatment
2020 .01
-
Expression levels of RUNX3 and FGFR2 in peripheral blood of severe acute pancreatitis and their clinical significance
Annals of Surgical Treatment and Research
2023 .02
-
Clinical management and emerging therapies of FGFR3-related skeletal dysplasia in childhood
Annals of Pediatirc Endocrinology & Metabolism
2022 .06
-
Oncogenic Activation of Fibroblast Growth Factor Receptor-3 and RAS Genes as Non-Overlapping Mutual Exclusive Events in Urinary Bladder Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
FGFR4 Arg388 Is Correlated with Poor Survival in Resected Colon Cancer Promoting Epithelial to Mesenchymal Transition
Cancer Research and Treatment
2017 .07
-
The First Case of B-lymphoblastic Leukemia Associated With t(7;8)(q34;p11.2) and FGFR1 Rearrangement
Annals of Laboratory Medicine
2022 .07
-
The effect of fibroblast growth factor receptor inhibition on resistance exercise training-induced adaptation of bone and muscle quality in mice
The Korean Journal of Physiology & Pharmacology
2022 .05
-
Analysis of The Effect of FGFR Inhibitor Alone or in Combination with Cannabidiol (CBD) in Colorectal Cancer
대한외과학회 학술대회 초록집
2020 .11
-
A diagnosis of hypochondroplasia by next generation sequencing
Journal of genetic medicine
2016 .01
-
Global Expanded Access Program for Pemigatinib in Patients with Previously Treated Locally Advanced or Metastatic Cholangiocarcinoma and Fibroblast Growth Factor Receptor Gene Alterations
Cancer Research and Treatment
2024 .07
-
Two cases of Antley-Bixler syndrome caused by mutations in different genes, FGFR2 and POR
Journal of genetic medicine
2016 .01
-
The Prognostic Significance of FGFR4 Gly388 Polymorphism in Esophageal Squamous Cell Carcinoma after Concurrent Chemoradiotherapy
Cancer Research and Treatment
2016 .01
-
Dizygotic twin sisters with normosmic idiopathic hypogonadotropic hypogonadism caused by an FGFR1 gene variant
Annals of Pediatirc Endocrinology & Metabolism
2020 .01
-
Genetic Syndromes Associated with Craniosynostosis
대한신경외과학회지
2016 .01
-
Skeletal mineralization: mechanisms and diseases
Annals of Pediatirc Endocrinology & Metabolism
2019 .01
-
A Case of Antley-Bixler Syndrome With a Novel Likely Pathogenic Variant (c.529G>C) in the POR Gene
Annals of Laboratory Medicine
2017 .01
-
VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma
Cancer Research and Treatment
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0