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논문 기본 정보

자료유형
학술저널
저자정보
Song, Sinyoung (Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine) Lee, Yeon Hoon (Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine) Hong, Joon Pio (Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine) Oh, Tae Suk (Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine)
저널정보
대한두개안면성형외과학회 Archives of craniofacial surgery : ACFS Archives of craniofacial surgery : ACFS 제19권 제3호
발행연도
2018.1
수록면
168 - 174 (7page)

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Background: Safety, efficacy, and time to onset of effect of botulinum toxin type A is of importance to persons who seek improvement in glabellar frown lines, but this has not been well studied. The aim of this study was to determine the safety, efficacy, and onset of action of a newly developed botulinum toxin type A (Nabota) for the treatment of glabellar frown lines. Methods: This was a single-arm, open-label, and phase 4 clinical study. Forty-two subjects with glabellar lines were treated with five times of intramuscular injection of 0.1 mL (4 U/0.1 mL) for a total of 20 U of Nabota. Efficacy and safety were assessed at 2, 3, 4, 5, and 14 days. Efficacy was assessed by the investigator and it was defined as a 1-point change on a 4-point scale. Results: Improvement in glabellar frown lines at maximum frown was observed in 85.4% of subjects 2 days after administration. Improvement in glabellar lines at rest was observed in 51.2% of subjects 2 days after administration, and the proportion of subjects showing improvement increased with time. No severe adverse events were recorded. Conclusion: Onset of action was observed in the majority of subjects by 2 days after administration of Nabota. In addition, Nabota was found to be safe and effective for the treatment of glabellar frown lines.

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