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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 604 - 610 (7page)
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We investigated the synergic anti-inflammatory activity of Gleditsia sinensis Lam. (GS) extract and Lactobacillus brevis KY21 both in vitro and in vivo. Western blot analysis and immunostaining showed that AKT phosphorylation that increased by the exposure of LPS were significantly decreased by the presence of either GS extract or L. brevis KY21. In addition, p65 intracellular transport was critically inhibited by GS extract and L. brevis KY21. We further studied these effects using an in vivo dextran sulfate sodium (DSS)-induced mouse model. Body weight, food intake, and clinical scores were dramatically decreased after treatment with DSS, whereas these effects were palliated by the addition of GS extract and L. brevis KY21. Importantly, transcription of genes encoding pro-inflammatory cytokines including IL-1β, TNF-α, and IFN-γ in mesenteric lymph nodes (MLN) and the spleen were increased by DSS treatment, whereas they were inhibited by the presence of GS extract and L. brevis KY21.
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참고문헌 (23)
참고문헌 신청
Abreu-Martin, M. T. / 1995 / Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-alpha and ligation of Fas antigen / J. Immunol 155:4147~4154
Baggiolini, M. / 1989 / Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils / J. Clin. Invest 84:1045~1049
Bamias, G. / 2012 / New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation / Cytokine 59:451~459
Bedaiwi, M. K. / 2014 / Microbiome and probiotics:Link to arthritis / Curr. Opin. Rheumatol 26:410~415
Chow, L. M. / 2003 / Gleditsia sinensis fruit extract is a potential chemotherapeutic agent in chronic and acute myelogenous leukemia / Oncol. Rep 10:1601~1607
Baggiolini, M. / 1989 / Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils / J. Clin. Invest 84:1045~1049
Bamias, G. / 2012 / New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation / Cytokine 59:451~459
Bedaiwi, M. K. / 2014 / Microbiome and probiotics:Link to arthritis / Curr. Opin. Rheumatol 26:410~415
Chow, L. M. / 2003 / Gleditsia sinensis fruit extract is a potential chemotherapeutic agent in chronic and acute myelogenous leukemia / Oncol. Rep 10:1601~1607
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