지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 1,050 - 1,054 (5page)
이용수
초록· 키워드
오류제보하기
Recently, arsenic compounds were considered as novel agents for treatment of acute promyelocytic leukemia and malignant tumors. However, it showed severe toxicity effect on normal tissue at the same time. In this study, to investigate the possible molecular mechanism (s) of arsenic compounds as candidate of anti-cancer drugs, we compared the abilities of two arsenic compounds, tetraarsenic oxide $(AS_4O_6)$ and arsenic trioxide (diarsenic oxide, $As_2O_3$), to induce cell growth inhibition as well as apoptosis induction in A549 human non-small cell lung cancer cells. Both $As_4O_6\;and\;As_2O_3$ treatment declined the cell growth and viability of A549 cells in a concentration-dependent manner, which was associated with induction of G1 arrest of the cell cycle and apoptotic cell death. However, $As_4O_6$ induced growth inhibition and apoptosis in A549 cells at much lower concentrations than $As_2O_3.\;As_4O_6$ down-regulated the levels of anti-apoptotic Bcl-2 protein, however, the levels of Bax, a pro-apoptotic protein, were up-regulated in a dose-dependent manner. In conclusion, $As_4O_6$ might be a new arsenic compound which may induce apoptosis in A549 cells by modulation the Bcl-2 family and deserves further evaluation.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
비소화합물에 의한 A549 폐암세포의 증식억제에 관한 연구
동의생리병리학회지
2005 .08
-
Cell Cycle, Cell Death and Apoptosis
대한핵의학회 연수교육
2002 .01
-
鬱金이 肺癌, 子宮癌, 神經膠腫 및 前立腺癌에 대한 細胞自殺誘導에 미치는 影響
대한한방내과학회지
2006 .01
-
Bax의 발현증가 및 Caspase의 활성을 통한 봉독약침액 Melittin의 인체폐암세포 Apoptosis 유발에 관한 연구
대한침구의학회지
2004 .01
-
Compound K induced apoptosis via endoplasmic reticulum Ca2+ release through ryanodine receptor in human lung cancer cells
Journal of Ginseng Research
2018 .04
-
Inhibitory Effect of Bee Venom Toxin on Lung Cancer NCI H460 Cells Growth Through Induction of Apoptosis via Death Receptor Expressions
대한침구의학회지
2014 .01
-
Harnessing of Programmed Necrosis for Fighting against Cancers
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Melittin Inhibits Human Prostate Cancer Cell Growth through Induction of Apoptotic Cell Death
Toxicological Research
2006 .03
-
瀉白散 추출물에 의한 인체 폐암세포의 Apoptosis 유도 기전에 관한 연구
동의생리병리학회지
2003 .04
-
Cannabidiol Induces Cytotoxicity and Cell Death via Apoptotic Pathway in Cancer Cell Lines
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
-
Inhibitory Effects of Bee Venom on Growth of A549 Lung Cancer Cells via Induction of Death Receptors
대한침구의학회지
2013 .01
-
Compound K, Ginseng Saponin Metabolite, Induces Apoptosis in Human Monocytic Leukemia cells
한국응용약물학회 추계학술발표논문집
2003 .01
-
The apoptotic mechanism of chloramquinone in human non-small cell lung cancer A549 cells
대한동의병리학회 학술대회논문집
2004 .12
-
상황보리 추출물에 의한 p21 및 Bax 발현 증가와 caspase 활성화를 통한 U937 인체백혈병 세포의 apoptosis 유발
동의생리병리학회지
2007 .10
-
Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Curcumin Inhibits Human Non-small Cell Lung Cancer A549 Cell Proliferation Through Regulation of Bcl-2/Bax and Cytochrome C
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Anti-proliferation Effects of Isorhamnetin on Lung Cancer Cells in Vitro and in Vivo
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Inhibitory Effect of Bee Venom Toxin on the Growth of Cervix Cancer C33A Cells via Death Receptor Expression and Apoptosis
대한침구의학회지
2014 .01
-
Inhibition of Proliferation and Induction of Apoptosis by EGCG in Human Osteogenic Sarcoma (HOS) Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Tetraarsenic O xide-mediated Apoptosis in a C ervical Cancer Cell Line, SiHa
Cancer Research and Treatment
2005 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0