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논문 기본 정보

자료유형
학술저널
저자정보
Yang, Seung-Ho (Department of Neurosurgery, Kangnam St. Mary's Hospital, The Catholic University of Korea) Lee, Kwan-Sung (Department of Neurosurgery, Kangnam St. Mary's Hospital, The Catholic University of Korea) Lee, Tae-Kyu (Department of Neurosurgery, Kangnam St. Mary's Hospital, The Catholic University of Korea) Jeun, Sin-Soo (Department of Neurosurgery, Kangnam St. Mary's Hospital, The Catholic University of Korea) Park, Chun-Kun (Department of Neurosurgery, Kangnam St. Mary's Hospital, The Catholic University of Korea) Hong, Yong-Kil (Department of Neurosurgery, Kangnam St. Mary's Hospital, The Catholic University of Korea)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제41권 제6호
발행연도
2007.1
수록면
387 - 390 (4page)

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Objective : To determine the presentation, incidence, and risk factors of seizures in patients treated for brain tumors. Methods : One hundred patients who consecutively underwent a craniotomy for the treatment of supratentorial brain tumors were assessed. The pathologies of the patients enrolled in the study included glioma [n=56], meningioma [n=31], metastatic brain tumor [n=7], primary central nervous system lymphoma [n=4], and central neurocytoma [n=2]. Anti-epileptic drugs [AEDs] were administered to all patients for up to six months after the surgery. Pre-defined variables for outcome analysis included tumor grade and location, extent of tumor resection, number of seizures, age at tumor diagnosis, adjuvant therapy, medication and radiological abnormalities. Results : Thirty patients [30%] presented at least a single episode of seizure at the time of admission. Five of these patients [16.7%] developed the seizure during the follow-up period. Newly developed seizure was noticed in six out of seventy patients [8.6%] without prior seizure. Histopathology was malignant gliomas in 10 and supratentorial meningioma in one. Early seizure developed only in two patients. Conclusion : Compared with patients without seizure, patients with seizure at the time of admission showed younger age [p=0.003], a higher portion of low-grade glioma [p=0.001], tumor location in the frontal and temporal lobes [p=0.003] and cortical involvement [p=0.017]. Our study suggestes that tumor progression is considered a significant risk factor for seizure development in glioma patients.

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