개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 470 - 474 (5page)
이용수
초록· 키워드
오류제보하기
Objective : The brain is dependent on glucose as an energy source. Intricate homeostatic mechanisms have been implicated in maintaining the blood glucose concentration in the brain. The aim of this study is to find the way to identify the metabolic proteins regulating the glucose in rat hypothalamus. Methods : In this study, we analysed the secretome from rat hypothalamus in vivo. We introduced 500 nM of insulin into the rat hypothalamus. The chromatographic patterns of the secretome were identified, after which Mass Spectrometry-Mass Spectrometry (MS-MS) analysis was performed. Results : In Liquid Chromatography-Mass Spectrometry (LC-MS) analysis, 60 proteins were identified in the secretome. Among them, 8 novel proteins were unveiled and were associated with the energy metabolism of insulin signaling in mitochondria of rat hypothalamic neuron. Nineteen other proteins have unknown functions. These ligands were confirmed to be secreting from the rat hypothalmus on insulin signaling by western blotting. Conclusion : The hypothalamus is the master endocrine gland responsible for the regulation of various physiological and metabolic processes. Proteomics using LC-MS analysis offer a efficient means for generating a comprehensive analysis of hypothalamic protein expression by insulin signaling.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Overexpression of Insulin Degrading Enzyme could Greatly Contribute to Insulin Down-regulation Induced by Short-Term Swimming Exercise
Laboratory Animal Research
2011 .03
-
Effect of Bisphenol A on Insulin-Mediated Glucose Metabolism In Vivo and In Vitro
Molecular & cellular toxicology
2008 .01
-
항정신병약물 클로자핀이 흰쥐 뇌실로 주입한 인슐린의 반응에 미치는 영향
생물정신의학
2012 .01
-
Insulin Receptor Substrate Proteins and Diabetes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
재조합 인슐린 치료 중 발생한 혈중 인슐린농도의 비정상적 상승 증례에 대한 고찰
Laboratory Medicine Online
2013 .01
-
Determination of Insulin Signaling Pathways in Hepatocytes
Toxicological Research
2005 .09
-
Insulin-siRNA와 human insulin degrading enzyme (hIDE)의 과발현이 당대사에 관여하는 insulin signaling에 미치는 영향
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Simultaneous Analysis of Benzophenone and its Analogs by gas chromatography/mass spectrometry in rat bloods
환경독성보건학회 심포지엄 및 학술대회
2005 .05
-
Manifestation of metabolic Aberration in Rat urine Following Hypothalamic Lesions
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1984 .01
-
재조합 사람 인슐린에 대한 알레르기반응 1예
Allergy Asthma & Respiratory Diseases
2015 .01
-
Signaling of Insulin and GnRH
대한생식의학회 학술대회
2005 .01
-
The Overexpression of Insulin-siRNA and Insulin Degrading Enzyme Decreases Insulin Levels In vitro and In vivo
Laboratory Animal Research
2005 .06
-
The Effects of Anti-insulin Antibodies and Cross-reactivity with Human Recombinant Insulin Analogues in the E170 Insulin Immunometric Assay
Annals of Laboratory Medicine
2011 .01
-
Design and Cloning of the Gene for a Novel Insulin Analogue, $(B^{30}$-Homoserine) Human Insulin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1993 .01
-
Blood glucose levels, insulin concentrations, and insulin resistance in healthy women and women with premenstrual syndrome: a comparative study
Clinical and experimental reproductive medicine : CERM
2013 .01
-
High throughput analysis of metabolic stability of dopamine receptor antagonists and identification of their metabolites by liquid chromatography/tandem mass spectrometry
대한약학회 학술대회
2002 .01
-
In vitro metabolic stability of sildenafil derivatives and identification of their metabolites by liquid chromatography/ion trap mass spectrometry
대한약학회 학술대회
2002 .01
-
Prolonged Antidiabetic Effect of Zinc-Crystallized Insulin Loaded Glycol Chitosan Nanoparticles in Type 1 Diabetic Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
단순 비만아에서 인슐린이 지질대사 이상에 미치는 영향
Clinical and Experimental Pediatrics
2002 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0