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논문 기본 정보

자료유형
학술저널
저자정보
Yoo Mi Kyong (School of Agricultural Biotechnology, Seoul National University) Choi Hoo Kyun (College of Pharmacy, Chosun University) Kim Tae Hee (School of Agricultural Biotechnology, Seoul National University) Choi Yun Jaie (School of Agricultural Biotechnology, Seoul National University) Akaike Toshihiro (Department of Biomolecular Engineering, Tokyo Institute of Technology) Shirakawa Mayumi (Danippon Pharmaceutical Co.) Cho Chong Su (School of Agricultural Biotechnology, Seoul National University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제28권 제6호
발행연도
2005.1
수록면
736 - 742 (7page)

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Xyloglucan (XG), which exhibits thermal sol to gel transition, non-toxicity, and low gelation concentration, is of interest in the development of sustained release carriers for drug delivery. Drug-loaded XG beads were prepared by extruding dropwise a dispersion of indomethacin in aqueous XG solution (2 wt.-$\%$) through a syringe into corn oil. Enteric coating of XG bead was performed using Eudragit L 100 to improve the stability of XG bead in gastrointestinal (GI) track and to achieve gastroresistant drug release. Release behavior of indomethacin from XG beads in vitro was investigated as a function of loading content of drug, pH of release medium, and concentration of coating agent. Adhesive force of XG was also measured using the tensile test. Uniform-sized spherical beads with particle diameters ranging from 692 $\pm$ 30 to 819 $\pm$ 50 $\mu$m were obtained. The effect of drug content on the release of indomethacin from XG beads depended on the medium pH. Release of indomethacin from XG beads was retarded by coating with Eudragit and increased rapidly with the change in medium pH from 1.2 to 7.4. Adhesive force of XG was stronger than that of Carbopol 943 P, a well-known commercial mucoadhesive polymer, in wet state. Results indicate the enteric-coated XG beads may be suitable as a carrier for oral drug delivery of irritant drug in the stomach.

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