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자료유형
학술저널
저자정보
Kang, Han-Ju (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) Kim, Kyung-Ho (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) Jo, Hyun-Seog (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) Hwang, Min-Seob (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University) Kim, Kap-Sung (Department of Acupuncture & Moxibustion, Graduate School of Oriental Medicine, Dongguk University)
저널정보
대한침구의학회 대한침구의학회지 Journal of acupuncture research 제22권 제2호
발행연도
2005.1
수록면
33 - 41 (9page)

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Objective : The effect of Ulmus davidiana Planch(UD), which has long been known to have anti-inflammation and protective effects on damaged tissue, inflammation and bone among other functions, on the development of type II collagen (CII)-induced arthritis (CIA) in rats was studied. Methods : Male rats were immunized with an emulsion of $200\;{\mu}g$ of CII and complete Freund's adjuvant (CFA). The rats were then given intraperitoneal stimulation of Ulmus davidiana Planch herbal acupuncture(UDHA)or saline during the experiment. When compared with rats treated with saline as control, UDHA at doses of more than $20{\mu}g/100\;g$ rat once a day for 7 days inhibited the ability of inguinal lymph node cells to produce T cell cytokines interleukin-2, interleukin-6, $IFN-{\gamma}$ when the cells were obtained from rats 14 days after immunization and cultured in vitro with CII. Results : When rats were injected intraperitoneally, UD -treated group and control group rats did not differ significantly when low doses of UD was given to rats. Conclusion : The recommended dose of UD in the management and treatment of rat CIA will be more than $20{\mu}g/100\;g$, which is two-firth of human therapeutic dose. From the results, it was concluded that the effect of UDHA is dependent of dosage.

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