Depurination of dA and dG Induced by 2-bromopropane at the Physiological Condition

Thapa, Pritam; Sherchan, Jyoti; Karki, Radha; Jeong, Tae-Cheon; Lee, Eung-Seok

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자료유형: 학술저널

저자정보: Thapa, Pritam (College of Pharmacy, Yeungnam University) Sherchan, Jyoti (College of Pharmacy, Yeungnam University) Karki, Radha (College of Pharmacy, Yeungnam University) Jeong, Tae-Cheon (College of Pharmacy, Yeungnam University) Lee, Eung-Seok (College of Pharmacy, Yeungnam University)

저널정보: 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 제15권 제4호

발행연도: 2007.1

수록면: 224 - 229 (6page)

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Depurination, the release of purine bases from nucleosides by hydrolysis of the N-glycosidic bond, gives rise to alterations of the cell genome. Although, cells have evolved mechanisms to repair these lesions, unrepaired apurinic sites have been shown to have two biological consequences: lethality and base substitution errors. 2-Bromopropane (2-BP) is used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organics. In addition, 2-BP has been used as a cleaning solvent in electronics industry. But, 2-BP was found to cause reproductive and hematopoietic disorders in local workers exposed to it. We observed massive depurination after incubation of 2'-deoxyadenosine (dA) and 2'-deoxyguanosine (dG) with the excess amount 2-BP at the physiological condition (pH 7.4, $37^{\circ}C$), which were analyzed by HPLC and LC-MS/MS. In addition, time and dose response relationship of depurination in dA and dG induced by 2-BP at the physiological condition were investigated.

#depurination #1-bromopropane #2-bromopropane #time and dose response relationship

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