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논문 기본 정보

자료유형
학술저널
저자정보
Yoo, Yung-Choon (Dept. of Microbiology, Konyang University, Konyang University Hospital) Kim, Woo-Jung (Dept. of Biotechnology and The Biomaterial Engineering Research Center, The Catholic University of Korea) Kim, So-Yeon (Dept. of Microbiology, Konyang University, Konyang University Hospital) Kim, Sung-Min (Dept. of Biotechnology and The Biomaterial Engineering Research Center, The Catholic University of Korea) Chung, Mi-Kyung (Biomedicine Research Group, Hanrib Life Tech, Bio 21 Center) Park, Joo-Woong (Biomedicine Research Group, Hanrib Life Tech, Bio 21 Center) Suh, Hyun-Hyo (Dept. of Environmental Engineering, Jinju National University) Lee, Kyung-Bok (Dept. of Microbiology, Konyang University, Konyang University Hospital) Park, Yong-Il (Dept. of Biotechnology and The Biomaterial Engineering Research Center, The Catholic University of Korea)
저널정보
한국조류학회(藻類) Algae Algae 제22권 제4호
발행연도
2007.1
수록면
333 - 338 (6page)

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초록· 키워드

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A fucoidan, isolated from Korean Undaria pinnatifida spoprophyll (UP-F), was investigated for its immunomodulating activity on murine macrophages and splenocytes, and its activity was compared with that of fucoidan from Fucus vesiculosus (FV-F). Treatment of UP-F resulted in inhibition of the growth of murine macrophage RAW 264.7 cells, but its cytotoxicity was not observed in normal murine splenocytes. FV-F was shown to be highly cytotoxic to both immune cells, and its cytotoxic activity was higher than that of UP-F. Treatment of UP-F induced TNF-α in a dose-dependent manner from two types of macrophages, RAW 264.7 cells and murine peritoneal macrophages. The TNF-α-inducing activity of UP-F was higher than that of FV-F. UP-F also actively induced chemokines (RANTES and MIP-1α) from RAW 264.7 cells. Furthermore, treatment of UP-F gave rise to activation of murine splenocytes to produce cytokine (IL-6) and chemokines (RANTES and MIP-1α), showing significantly higher activity than that of FV-F. These results indicate that UP-F is less cytotoxic to immune cells than FV-F, and possesses immunomodulating activity to produce cytokines and chemokines from macrophages and splenocytes.

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