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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 26 - 45 (20page)
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초록· 키워드
오류제보하기
The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. Benzimidazole anthelmintics have broad-spectrum action to remove parasites both in human and veterinary medicine. In addition to being antiparasitic agents, benzimidazole anthelmintics are known to exert anticancer activities, such as the disruption of microtubule polymerization, the induction of apoptosis, cell cycle (G2/M) arrest, anti-angiogenesis, and blockage of glucose transport. These antitumorigenic effects even extend to cancer cells resistant to approved therapies and when in combination with conventional therapeutics, enhance anticancer efficacy and hold promise as adjuvants. Above all, these anthelmintics may offer a broad, safe spectrum to treat cancer, as demonstrated by their long history of use as antiparasitic agents. The present review summarizes central literature regarding the anticancer effects of benzimidazole anthelmintics, including albendazole, parbendazole, fenbendazole, mebendazole, oxibendazole, oxfendazole, ricobendazole, and flubendazole in cancer cell lines, animal tumor models, and clinical trials. This review provides valuable information on how to improve the quality of life in patients with cancers by increasing the treatment options and decreasing side effects from conventional therapy.
목차
ABSTRACT
INTRODUCTION
ANTITUMORIGENIC EFFECTS OF BENZIMIDAZOLE ANTHELMINTICS IN CANCER CELLS
ANTITUMORIGENIC EFFECTS OF BENZIMIDAZOLE ANTHELMINTICS IN ANIMAL TUMOR MODELS
ANTITUMORIGENIC EFFECTS OF BENZIMIDAZOLE ANTHELMINTICS IN CLINICAL ASPECTS
PHARMACOKINETIC PROPERTIES AND SIDE EFFECTS OF BENZIMIDAZOLE ANTHELMINTICS
SUMMARY
REFERENCES
참고문헌 (115)
참고문헌 신청
Furtado LFV / 2016 / Benzimidazole resistance in helminths : from problem to diagnosis / Acta Trop 162:95~102
Friedman PA / 1980 / Interaction of anthelmintic benzimidazoles with Ascaris suum embryonic tubulin / Biochim Biophys Acta 630:271~278
Cleeland CS / 2012 / Reducing the toxicity of cancer therapy : recognizing needs, taking action / Nat Rev Clin Oncol 9:471~478
Tang Y / 2017 / Co-delivery of trichosanthin and albendazole by nano-self-assembly for overcoming tumor multidrug-resistance and metastasis / ACS Appl Mater Interfaces 9:26648~26664
Dayan AD / 2003 / Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics / Acta Trop 86:141~159
Friedman PA / 1980 / Interaction of anthelmintic benzimidazoles with Ascaris suum embryonic tubulin / Biochim Biophys Acta 630:271~278
Cleeland CS / 2012 / Reducing the toxicity of cancer therapy : recognizing needs, taking action / Nat Rev Clin Oncol 9:471~478
Tang Y / 2017 / Co-delivery of trichosanthin and albendazole by nano-self-assembly for overcoming tumor multidrug-resistance and metastasis / ACS Appl Mater Interfaces 9:26648~26664
Dayan AD / 2003 / Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics / Acta Trop 86:141~159
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