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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.5
- 발행연도
- 2020.11
- 수록면
- 251 - 258 (8page)
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초록· 키워드
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Purpose: Although metastasis occurs in 1 or 2 sentinel lymph nodes (SLNs), axillary lymph node dissection (ALND) has been widely not performed. For axillary staging and management, the necessity of intraoperative frozen section analysis of SLN has been controversial. The aim of this study is to evaluate the validity and benefit of SLN analysis by permanent section alone in clinically negative lymph node breast cancer patients.
Methods: We conducted a retrospective study of 283 cases with negative node clinical findings between July 2018 and August 2019 in Samsung Medical Center. Clinical nodal stage was evaluated by physical examination, breast ultrasonography, breast magnetic resonance imaging, and chest computerized tomography. The cases were divided into 2 groups; the permanent group had 151 cases (53.4%) and the frozen group had 132 cases (46.6%). We retrospectively analyzed the differences in the number of metastatic lymph nodes and rates of performed ALND between the 2 groups.
Results: Baseline and clinicopathologic characteristics between the 2 groups were well balanced. Three cases in the permanent group and 6 cases in the frozen group underwent additional or immediate ALND. The rates of ALND between the 2 groups were not significantly different (P = 0.312). The cased of 78.9% and 89.5% with metastatic lymph nodes in permanent and frozen groups were in the pathologic N1 stage, respectively.
Conclusion: SLNs analysis by permanent section alone may be performed in clinically negative axillary node breast cancer patients. Our findings can help to avoid unnecessary intraoperative frozen section analysis.
Methods: We conducted a retrospective study of 283 cases with negative node clinical findings between July 2018 and August 2019 in Samsung Medical Center. Clinical nodal stage was evaluated by physical examination, breast ultrasonography, breast magnetic resonance imaging, and chest computerized tomography. The cases were divided into 2 groups; the permanent group had 151 cases (53.4%) and the frozen group had 132 cases (46.6%). We retrospectively analyzed the differences in the number of metastatic lymph nodes and rates of performed ALND between the 2 groups.
Results: Baseline and clinicopathologic characteristics between the 2 groups were well balanced. Three cases in the permanent group and 6 cases in the frozen group underwent additional or immediate ALND. The rates of ALND between the 2 groups were not significantly different (P = 0.312). The cased of 78.9% and 89.5% with metastatic lymph nodes in permanent and frozen groups were in the pathologic N1 stage, respectively.
Conclusion: SLNs analysis by permanent section alone may be performed in clinically negative axillary node breast cancer patients. Our findings can help to avoid unnecessary intraoperative frozen section analysis.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
Kel ley MC / 2004 / Lymphatic mapping and sentinel lymphadenectomy for breast cancer / Am J Surg 188:49~61
van der Noordaa ME / 2017 / The intraoperative assessment of sentinel nodes : standards and controversies / Breast 34(Suppl 1):S64~S69
Giuliano AE / 2017 / Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis : the ACOSOG Z0011(Alliance)randomized clinical trial / JAMA 318:918~926
Donker M / 2014 / Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer(EORTC 10981-22023 AMAROS) : a randomised, multicentre, open-label, phase 3 non-inferiority trial / Lancet Oncol 15:1303~1310
Poling JS / 2014 / Frozen section evaluation of breast carcinoma sentinel lymph nodes : a retrospective review of 1, 940 cases / Breast Cancer Res Treat 148:355~361
van der Noordaa ME / 2017 / The intraoperative assessment of sentinel nodes : standards and controversies / Breast 34(Suppl 1):S64~S69
Giuliano AE / 2017 / Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis : the ACOSOG Z0011(Alliance)randomized clinical trial / JAMA 318:918~926
Donker M / 2014 / Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer(EORTC 10981-22023 AMAROS) : a randomised, multicentre, open-label, phase 3 non-inferiority trial / Lancet Oncol 15:1303~1310
Poling JS / 2014 / Frozen section evaluation of breast carcinoma sentinel lymph nodes : a retrospective review of 1, 940 cases / Breast Cancer Res Treat 148:355~361
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UCI(KEPA) : I410-ECN-0101-2020-514-001571494