지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.10
- 수록면
- 513 - 525 (13page)
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초록· 키워드
오류제보하기
Clonorchis sinensis is a food-borne trematode that infects more than 15 million people. The liver fluke causes clonorchiasis and chronical cholangitis, and promotes cholangiocarcinoma. The underlying molecular pathogenesis occurring in the bile duct by the infection is little known. In this study, transcriptome profile in the bile ducts infected with C. sinensis were analyzed using microarray methods. Differentially expressed genes (DEGs) were 1,563 and 1,457 at 2 and 4 weeks after infection. Majority of the DEGs were temporally dysregulated at 2 weeks, but 519 DEGs showed monotonically changing expression patterns that formed seven distinct expression profiles. Protein-protein interaction (PPI) analysis of the DEG products revealed 5 sub-networks and 10 key hub proteins while weighted co-expression network analysis (WGCNA)-derived gene-gene interaction exhibited 16 co-expression modules and 13 key hub genes. The DEGs were significantly enriched in 16 Kyoto Encyclopedia of Genes and Genomes pathways, which were related to original systems, cellular process, environmental information processing, and human diseases. This study uncovered a global picture of gene expression profiles in the bile ducts infected with C. sinensis, and provided a set of potent predictive biomarkers for early diagnosis of clonorchiasis.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (57)
참고문헌 신청
Everhart JE / 2009 / Burden of digestive diseases in the United States Part III : Liver, biliary tract, and pancreas / Gastroenterology 136:1134~1144
1994 / Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994 / IARC Monogr Eval Carcinog Risks Hum 61:1~241
Sawanyawisuth K / 2012 / Serial analysis of gene expression reveals promising therapeutic targets for liver fluke-associated cholangiocarcinoma / Asian Pac J Cancer Prev 13(suppl):89~93
Yongvanit P / 2012 / Oxidative and nitrative DNA damage : key events in opisthorchiasis-induced carcinogenesis / Parasitol Int 61:130~135
Pak JH / 2009 / Differential gene expression profiling in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products / Parasitol Res 104:1035~1046
1994 / Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994 / IARC Monogr Eval Carcinog Risks Hum 61:1~241
Sawanyawisuth K / 2012 / Serial analysis of gene expression reveals promising therapeutic targets for liver fluke-associated cholangiocarcinoma / Asian Pac J Cancer Prev 13(suppl):89~93
Yongvanit P / 2012 / Oxidative and nitrative DNA damage : key events in opisthorchiasis-induced carcinogenesis / Parasitol Int 61:130~135
Pak JH / 2009 / Differential gene expression profiling in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products / Parasitol Res 104:1035~1046
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UCI(KEPA) : I410-ECN-0101-2020-513-001565111