지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.11
- 수록면
- 808 - 814 (7page)
이용수
초록· 키워드
오류제보하기
Background: Korean Red Ginseng extract (RGE) has been reported to act as an inflammasome modulator. Ginsenosides, saponin molecules of RGE, selectively inhibit activation of NLRP3 and AIM2 inflammasomes, while non-saponin molecules of RGE upregulate inflammasome components associated with the initiation of NLRP3 inflammasome activation. In this study, we investigated the effect of non-saponin components of RGE on AIM2 inflammasome activation.
Methods: The role of non-saponins of RGE on AIM2 inflammasomes was tested in mouse bone marrow-derived macrophages, a human monocyte-like cell line, and a mouse animal model. Cells or mice were transfected with dsDNA or inoculated with Listeria monocytogenes to activate AIM2 inflammasomes. Several indices of inflammasome activation were examined via immunoblot or ELISA analysis.
Results: The non-saponin fraction and saponin-eliminating fraction (SEF) of RGE selectively attenuated the activation of AIM2 inflammasomes, but not that of NLRP3 or NLRC4 inflammasomes. Fructose-arginine, an amino-sugar, was shown to be effective against AIM2 inflammasome activation.
Conclusion: Non-saponins of RGE, such as fructose-arginine, might be effective in regulating infectious and autoimmune diseases resulting from AIM2 inflammasome activation.
Methods: The role of non-saponins of RGE on AIM2 inflammasomes was tested in mouse bone marrow-derived macrophages, a human monocyte-like cell line, and a mouse animal model. Cells or mice were transfected with dsDNA or inoculated with Listeria monocytogenes to activate AIM2 inflammasomes. Several indices of inflammasome activation were examined via immunoblot or ELISA analysis.
Results: The non-saponin fraction and saponin-eliminating fraction (SEF) of RGE selectively attenuated the activation of AIM2 inflammasomes, but not that of NLRP3 or NLRC4 inflammasomes. Fructose-arginine, an amino-sugar, was shown to be effective against AIM2 inflammasome activation.
Conclusion: Non-saponins of RGE, such as fructose-arginine, might be effective in regulating infectious and autoimmune diseases resulting from AIM2 inflammasome activation.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Fructose-arginine regulates AIM2 inflammasome activation
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Non-saponin fractions of Korean Red Ginseng inhibit AIM2 inflammasome activation
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome
Journal of Ginseng Research
2017 .10
-
Korean Red Ginseng attenuates ultraviolet-mediated inflammasome activation in keratinocytes
Journal of Ginseng Research
2021 .05
-
Horse inflammasomes and the signal pathways
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Potential benefits of ginseng against COVID-19 by targeting inflammasomes
Journal of Ginseng Research
2022 .11
-
Protective role of saponin derived from Korean Red Ginseng in keratinocytes
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Korean Red Ginseng, a regulator of NLRP3 inflammasome, in the COVID-19 pandemic
Journal of Ginseng Research
2022 .05
-
Maltol, a compound in Korean Red Ginseng, attenuates the Staphylococcus aureus-induced inflammasome activation in the skin
Journal of Ginseng Research
2024 .11
-
Effect of lentinan on the inflammasome activation in mouse macrophages
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Inhibitory effect of Cheonggukjang extracts on inflammasome activation and radiation-induced micronucleus formation
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Inflammasome as a Therapeutic Target for Cancer Prevention and Treatment
대한암예방학회지
2017 .01
-
Roles of ginsenosides in inflammasome activation
Journal of Ginseng Research
2019 .04
-
Methylene blue inhibits inflammasome activation
한국실험동물학회 학술발표대회 논문집
2018 .01
-
A20 Protects Against Arthritis by Regulation of the NLRP3 Inflammasome
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .09
-
Inhibitory effect of Makgeolli extracts on Micronuclei formation and inflammasome activation
한국실험동물학회 학술발표대회 논문집
2015 .08
-
The NLRP3 inflammasome is inhibited in natural products, protecting against acute gout
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Riboflavin regulates inflammasome activation
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Green chilli extract`s Radio-Protective effect including inhibition of inflammasome activation and micronuclei formation
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Ginseng saponin enriched in Rh1 and Rg2 ameliorates non-alcoholic fatty liver disease by inhibiting inflammasome activation
한국실험동물학회 학술발표대회 논문집
2021 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0