메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats
Recommendations
Search
Questions

논문 기본 정보

Type
Academic journal
Author
Benxi Xiao (Guangdong Academy of Medical Sciences) Wenjun Ma (Guangdong Academy of Medical Sciences) Ying Zheng (Guangdong Academy of Medical Sciences) Zhen Li (Guangdong Academy of Medical Sciences) Dan Li (School of Public Health in Sun Yat-sen University) Yanjun Zhang (Guangdong Academy of Medical Sciences)
Journal
The Korean Nutrition Society Nutrition Research and Practice Vol.15 No.1 KCI Accredited Journals SCIE
Published
2021.2
Pages
26 - 37 (12page)

Usage

cover
📌
Topic
📖
Background
🔬
Method
🏆
Result
Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats
Ask AI
Recommendations
Search
Questions

Abstract· Keywords

Report Errors
BACKGROUND/OBJECTIVES: Hyperuricemic nephropathy is a common cause of acute kidney injury. Resveratrol can ameliorate kidney injury, but the explicit mechanism remains unclear. We investigated the effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats.
MATERIALS/METHODS: A rat model of hyperuricemic nephropathy was established by the oral administration of a mixture of adenine and potassium oxinate. Biochemical analysis and hematoxylin and eosin staining were performed to assess the rat kidney function. Enzymelinked immunosorbent assays were performed to evaluate the immune and oxidative responses.
RESULTS: The expression levels of urine albumin and β2-microglobulin were significantly decreased after resveratrol treatment. In addition, the levels of serum creatinine and uric acid were significantly decreased in the resveratrol groups, compared with the control group. The levels of proinflammatory factors, such as interleukin-1β and tumor necrosis factor-α, in kidney tissue and serum were also increased in the hyperuricemic rats, and resveratrol treatment inhibited their expression. Moreover, the total antioxidant capacity in kidney tissue as well as the superoxide dismutase and xanthine oxidase levels in serum were all decreased by resveratrol treatment.
CONCLUSIONS: Resveratrol may protect against hyperuricemic nephropathy through regulating the inflammatory response.
#Hyperuricemia #resveratrol #kidney diseases #inflammation #anti-oxidative effect

Contents

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

References (0)

Add References
If the reference is being serviced by DBpia, please register through [Add Reference]

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Recently viewed articles

A Study on the Types and Determinants of Longitudinal Changes in the Economic Preparations for the aging Among People with Physical Disabilities: Using Latent Class Growth Model
LEEGYESEUNG, Dong Ha Kim2017

Comments(0)

0

Write first comments.

UCI(KEPA) : I410-ECN-0101-2021-594-001431255