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Physicochemical properties and physiological activities of Agastache rugosa extracts
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배초향 추출물의 이화학적 품질 특성 및 생리활성

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Type
Academic journal
Author
Ji Wan Kim (대구가톨릭대학교) Joo-Heon Hong (대구가톨릭대학교)
Journal
The Korean Society of Food Preservation Food Science and Preservation Vo.28 No.1 KCI Accredited Journals SCOPUS
Published
2021.2
Pages
88 - 98 (11page)

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Physicochemical properties and physiological activities of Agastache rugosa extracts
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Agastache rugosa is used as a medicinal herb and contains various polyphenol compounds. Here, we investigated the physicochemical properties; and the immunomodulatory and anti-obesity effects of Agastache rugosa extracts. Agastache rugosa was extracted with hot water (HE), 70% ethanol (EE), and 70% methanol (ME). The yield of Agastache rugosa extracts varied depending on the extraction solvents, from 6.11 to -8.86%. The total sugar content was the highest in the HE -(33.98 g/100 g). In contrast, the total polyphenol content was the highest in the ME -(10.25 g/100 g), while the total protein content was similar in all extracts. The DPPH radical scavenging activity of the ME was 61.05%, and the ABTS radical scavenging activity of the EE was 47.73% at 1,000 ㎍/mL. Additionally, the FRAP activity and ORAC value of the EE at 1,000 ㎍/mL were 1.14 μM and 121.03 μM TE/g, respectively. Importantly, all extracts decreased the production of nitric oxide in RAW 264.7 cells, and the cytokine content also decreased in a concentration-dependent manner. In addition, all extracts decreased lipid accumulation in adipocytes in vitro, compared with that in the untreated adipocytes. Therefore, Agastache rugosa extracts can potentially be used as functional materials with immunomodulatory and anti-obesity effects.
#Agastache rugosa #physicochemical properties #antioxidants #immunomodulatory effect #anti-obesity activity

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Anderson JW / 1986 / Dietary Fiber :343~360 google schola Benzie IFF / 1996 / The ferric reducing ability of plasma(FRAP)as a measure of"antioxidant power" : The FRAP assay / Anal Biochem 239:70~76 google schola Blois MS / 1958 / Antioxidant determinations by the use of a stable free radical / Nature 181:1199~1200 google schola Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72:248~254 google schola Castoldi A / 2016 / The macrophage switch in obesity development / Front Immunol 6:637 google schola

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