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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.2
- 수록면
- 84 - 94 (11page)
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초록· 키워드
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Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its utility as a vaccine vector has continued to increase. Adenovirus-based vaccines are currently being tested not only to prevent various infectious diseases but also to be applied as cancer vaccines. In this review, I discuss the innate and adaptive aspects of the immunological characteristics of adenovirus vectors and further examine the current status of advanced adenovirus-based vaccine development. Various methods that can overcome the limitations of currently used adenoviruses as vaccine vehicles are also discussed. Through this study, I hope that vaccine development using adenovirus vectors will be expedited and more successful.
목차
ABSTRACT
INTRODUCTION
INTERACTIONS BETWEEN ADENOVECTORS AND THEIMMUNE SYSTEM
CURRENT STATUS OF ADENOVIRUS-BASED VACCINEDEVELOPMENT
CHALLENGES OF AND SOLUTIONS FOR ADENOVIRALVECTORS
CONCLUSION
REFERENCES
참고문헌 (56)
참고문헌 신청
Farina SF / 2001 / Replicationdefective vector based on a chimpanzee adenovirus / J Virol 75:11603~11613
Afkhami S / 2016 / Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens / Mol Ther Methods Clin Dev 3:16030
Lasaro MO / 2009 / New insights on adenovirus as vaccine vectors / Mol Ther 17:1333~1339
Majhen D / 2014 / Adenovirus-based vaccines for fighting infectious diseases and cancer : progress in the field / Hum Gene Ther 25:301~317
Bolinger B / 2015 / Adenoviral vector vaccination induces a conserved program of CD8(+)T cell memory differentiation in mouse and man / Cell Reports 13:1578~1588
Afkhami S / 2016 / Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens / Mol Ther Methods Clin Dev 3:16030
Lasaro MO / 2009 / New insights on adenovirus as vaccine vectors / Mol Ther 17:1333~1339
Majhen D / 2014 / Adenovirus-based vaccines for fighting infectious diseases and cancer : progress in the field / Hum Gene Ther 25:301~317
Bolinger B / 2015 / Adenoviral vector vaccination induces a conserved program of CD8(+)T cell memory differentiation in mouse and man / Cell Reports 13:1578~1588
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UCI(KEPA) : I410-ECN-0101-2021-517-001563497