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논문 기본 정보

자료유형
학술저널
저자정보
Yeonjeong Ha (The University of Texas at Austin) Xianzhe Wang (The University of Texas at Austin) Howard M. Liljestrand (The University of Texas at Austin) Jennifer A. Maynard (The University of Texas at Austin) Lynn E. Katz (The University of Texas at Austin)
저널정보
대한환경공학회 Environmental Engineering Research Environmental Engineering Research 제27권 제2호
발행연도
2022.4
수록면
173 - 182 (10page)

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Understanding the molecular interactions between biological cells and engineered nanoparticles is a key to evaluating potential toxicities to humans and the environment. This study developed a method to determine the mechanisms by which fullerene aggregates are distributed into a representative cell line, human intestinal Caco-2 cells. First, we determined that the presence of fetal bovine serum (FBS) in the cell culture media changes the particle characteristics and inhibits particle adsorptions onto cell surfaces. Second, significantly lower amounts of fullerene were internalized at 4°C, a temperature at which active transport mechanisms are effectively impeded, than at 37°C. Third, metabolic inhibitors of active transport and a microtubule transport inhibitor decreased fullerene uptake at 37°C. Fourth, cellular uptake of fullerene increased with increasing fullerene concentration, suggesting that passive diffusion into lipid membranes contributed to uptake over the broad concentration range used in this study. Together, these results indicate fullerene transport into cells occurs via two mechanisms: passive diffusion across the lipid bilayer and active transport including microtubule involved endocytosis. The results also suggest that simple physical-chemical partitioning models do not fully describe fullerene uptake, and instead, active transport models are also required to estimate the cellular uptake and toxicity of fullerene.

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ABSTRACT
1. Introduction
2. Experimental Sections
3. Results and Discussion
4. Conclusions
References

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