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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.2
- 수록면
- 67 - 76 (10page)
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Legionella pneumophila is an opportunistic pathogen that survives and proliferates within protists such as Acanthamoeba spp. in environment. However, intracellular pathogenic endosymbiosis and its implications within Acanthamoeba spp. remain poorly understood. In this study, RNA sequencing analysis was used to investigate transcriptional changes in A. castellanii in response to L. pneumophila infection. Based on RNA sequencing data, we identified 1,211 upregulated genes and 1,131 downregulated genes in A. castellanii infected with L. pneumophila for 12 hr. After 24 hr, 1,321 upregulated genes and 1,379 downregulated genes were identified. Gene ontology (GO) analysis revealed that L. pneumophila endosymbiosis enhanced hydrolase activity, catalytic activity, and DNA binding while reducing oxidoreductase activity in the molecular function (MF) domain. In particular, multiple genes associated with the GO term ‘integral component of membrane’ were downregulated during endosymbiosis. The endosymbiont also induced differential expression of various methyltransferases and acetyltransferases in A. castellanii. Findings herein are may significantly contribute to understanding endosymbiosis of L. pneumophila within A. castellanii.
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참고문헌 (20)
참고문헌 신청
Visvesvara GS / 2007 / Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea / FEMS Immunol Med Microbiol 50:1~26
Schmitz-Esser S / 2008 / Diversity of bacterial endosymbionts of environmental Acanthamoeba isolates / Appl Environ Microbiol 74:5822~5831
Greub G / 2004 / Microorganisms resistant to free-living amoebae / Clin Microbiol Rev 17:413~433
Richards AM / 2013 / Cellular microbiology and molecular ecology of Legionella-amoeba interaction / Virulence 4:307~314
Barker J / 1994 / Trojan horses of the microbial world: protozoa and the survival of bacterial pathogens in the environment / Microbiology 140:1253~1259
Schmitz-Esser S / 2008 / Diversity of bacterial endosymbionts of environmental Acanthamoeba isolates / Appl Environ Microbiol 74:5822~5831
Greub G / 2004 / Microorganisms resistant to free-living amoebae / Clin Microbiol Rev 17:413~433
Richards AM / 2013 / Cellular microbiology and molecular ecology of Legionella-amoeba interaction / Virulence 4:307~314
Barker J / 1994 / Trojan horses of the microbial world: protozoa and the survival of bacterial pathogens in the environment / Microbiology 140:1253~1259
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