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- 학술대회자료
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- 발행연도
- 2021.4
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- 19 - 19 (1page)
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Immune cell-based therapy, particularly genetically modified T cells such as CAR-engineered T cells has shown promise in treating certain blood cancers including acute lymphoblastic leukemia and non-Hodgkin lymphomas. However, clinical utility of CAR-engineered T cells in the context of chronic lymphoblastic leukemia and solid cancer has been questionable. Efficacious and persistent CAR-T cells should be resistant to tumor-associated deleterious immunosuppressive molecules such as TGFβ and/or Prostaglandin E2 (PGE2) and effectively establish long-term memory T cells without exhaustion. Tumor-associated inhibitory signals can dampen the activity of T cells, impeding the anticancer functions of T cells. Many studies have focused on PD-1 or CTLA-4 blockade to invigorate T-cell functions through CD28 signaling, however obtaining robust clinical outcomes remains challenging. To overcome inhibitory tumor-associated microenvironment, we propose downregulation of diacylglycerol kinase (DGK), as it metabolizes diacylglycerol (DAG) to phosphatidic ac ... 전체 초록 보기
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