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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 111 - 111 (1page)
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Recent biotechnological progress, particularly in the areas of genetic/genomic engineering, synthetic biology, systems biology, and metabolic engineering, offers novel tools to customize cell factories for bio-based production. The production of bio-based bulk chemicals from renewable bioresources has gained great attention in the scientific community as the process could avoid and/or minimize the negative impacts of the conventional chemical-based productions on the environment and depleting resources of natural petrochemicals. An inducible promoter is a crucial component for microbial-based chemical production. The induction of promoter expression by the addition of chemical inducers such IPTG is considered the most efficient method. However, it has the following limitations, such as the requirement of cell growth monitoring for the addition of chemical inducers at the optimal cell density, not feasible with industrial scale-up, and undesirable because of its toxicity and cost. Moreover, constitutive expression or strong expression of synthetic pathway genes can cause growth inhibition, less glucose consumption, and reduce product yield. Thus, inexpensive carbon source- or substrate-inducible systems are considered as one of the efficient systems for biosynthesis of chemicals, especially at industrial scale. 2,3-Butanediol (BDO), an important platform chemical, has many industrial applications and ... 전체 초록 보기
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