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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 615 - 615 (1page)
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When exposed to extraordinarily high osmolality, the cells undergo numerous perturbations, such as increased DNA strand breaks, cell cycle arrest and elevated reactive oxygen species (ROS). However, when the osmotic stress increases, the cells spontaneously accumulate organic osmolytes such as sorbitol as a self-defense mechanism. Sorbitol is synthesized from glucose, catalyzed by aldose reductase (AR), and it is metabolized to fructose by sorbitol dehydrogenase. The AR serves as an osmoregulatory role because its transcription level is increased in order to maintain intracellular osmolality under hyperosmotic condition. During fed-batch which is widely used to enhance the productivity of the therapeu ... 전체 초록 보기
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