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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 105 - 110 (6page)
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초록· 키워드
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Short Tandem Repeats (STR) analysis which characterized by genetic polymorphism has been widely used in the forensic genetic fields. Unfortunately, mutation occurred in various STR loci could make it difficult to interpret STR data. Thus, the mutation rate of STR loci plays an important role for the data interpretation in human identification and paternity test. To verify the mutation of the STR loci in the Korean population, 545 trio sets (father, mother, and child) were analyzed with two commercial STR kits that include the 23 autosomal STR loci (D1S1656, TPOX, D2S441, D2S1338, D3S1358, FGA, D5S818, CSF1PO, D7S820, D8S1179, D10S1248, TH01, D12S391, VWA D13S317, D16S539, D18S51, D19S433, D21S11, D22S1045, SE33, Penta E and Penta D). As a result, 36 mutations were observed in 14 STR loci. The types of mutation were also classified by the increase or decrease of the alleles. The overall mutation rate was 1.4×10<SUP>-3</SUP>, and the paternal mutation rate was four times higher than that of the maternal. This study will provide more detailed criterion for human identification by the mutation rate of STR loci in the Korean population.
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참고문헌 (21)
참고문헌 신청
Aşicioǧlu F / 2004 / Mutation rate at commonly used forensic STR loci : Paternity testing experience / Dis Markers 20:313~315
Brinkmann B / 1998 / Mutation Rate in Human Microsatellites : Influence of the Structure and Length of the Tandem Repeat / Am J Hum Genet 62:1408~1415
Budowle B / 2001 / CODIS STR Loci Data from 41 sample Populations / J Forensic Sci 46:453~489
Butler JM / 2007 / Short tandem repeat typing technologies used in human identity testing / Biotechniques
Butler JM / 2012 / Advanced Topics in Forensic DNA Typing: Methodology, Advanced Topics in Forensic DNA Typing: Methodology
Brinkmann B / 1998 / Mutation Rate in Human Microsatellites : Influence of the Structure and Length of the Tandem Repeat / Am J Hum Genet 62:1408~1415
Budowle B / 2001 / CODIS STR Loci Data from 41 sample Populations / J Forensic Sci 46:453~489
Butler JM / 2007 / Short tandem repeat typing technologies used in human identity testing / Biotechniques
Butler JM / 2012 / Advanced Topics in Forensic DNA Typing: Methodology, Advanced Topics in Forensic DNA Typing: Methodology
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