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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi on ovalbumin (OVA)-induced mouse asthma model. In this study, we examined the effect of F. amomi on OVA-induced asthma by analyzing Th1/Th2 cytokine production, histopathologic changes, and focusing on the NF-κB signaling. Oral administration of F. amomi reduced the number of inflammatory cells especially eosinophils and improved airway and pulmonary inflammation in the lungs of OVA-challenged mice. In addition, F. amomi significantly downregulated the overproduction of tumor necrosis factor-α, IL-1β, IL-4, IL-5 and the levels of OVA-specific both IgE and IgG1 and increased the secretion of interferon-γ and OVA-specific IgG2a. Moreover, F. amomi suppressed the increase of total NF-κB level and the phosphorylation of IκB-α and NF-κB by OVA. F. amomi may have therapeutic effect for allergic asthma by modulating Th1/Th2 cytokine imbalance and inhibiting NF-κB signaling activation.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
Lambrecht BN / 2015 / The immunology of asthma / Nat Immunol 16:45~56
You-Sun Kim / 2010 / IL-12-STAT4-IFN-γ axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model / Experimental and Molecular Medicine 42(8):533~546
Woodruff PG / 2009 / T-helper type 2-driven inflammation defines major subphenotypes of asthma / Am J Respir Crit Care Med 180:388~395
Abdelmotelb AM / 2014 / Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma / Clin Exp Allergy 44:822~830
Punnonen J / 1994 / Role of interleukine-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells / Allergy 49:576~586
You-Sun Kim / 2010 / IL-12-STAT4-IFN-γ axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model / Experimental and Molecular Medicine 42(8):533~546
Woodruff PG / 2009 / T-helper type 2-driven inflammation defines major subphenotypes of asthma / Am J Respir Crit Care Med 180:388~395
Abdelmotelb AM / 2014 / Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma / Clin Exp Allergy 44:822~830
Punnonen J / 1994 / Role of interleukine-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells / Allergy 49:576~586
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UCI(KEPA) : I410-ECN-0101-2021-511-001875289