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Tp53 Mutation Is Linked with High 21-Gene Recurrence Score in ER+/HER2- Breast Cancer
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Type
Proceeding
Author
Jung Hwan Ji (Yonsei University College of Medicine) Soong June Bae (Yonsei University College of Medicine) Sung Gwe Ahn (Yonsei University College of Medicine)
Journal
The Korean Surgical Society 대한외과학회 학술대회 초록집 2021년 대한외과학회 춘계학술대회
Published
2021.5
Pages
187 - 187 (1page)

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Result
Tp53 Mutation Is Linked with High 21-Gene Recurrence Score in ER+/HER2- Breast Cancer
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Purpose
The Oncotype DX 21-gene recurrence score (21-gene RS), which is most widely used multi-gene test to predict a prognosis and determine adjuvant chemotherapy, is known to be associated with endocrine resistance in ER+/HER2- breast cancer. Several lines of evidence support that TP53 mutation is associated with endocrine resistance in ER+ breast cancer. To date, there is no report regarding the relationship between TP53 mutation and 21-gene recurrence score. We investigated whether TP53 mutation is linked with 21-gene RS in patients with ER+/HER2- breast cancer. We further evaluated molecular characteristics of ER+/HER2- breast cancer according to TP53 mutation using the TCGA.

Method
We identified 141 patients who underwent TP53 gene sequencing and Oncotype DX test between August 2011 and March 2020 at a single institute. Mutational analysis of the TP53 gene was carried out using TP53 Sanger direct sequencing or targeted NGS with the Oncomine™ comprehensive panel (Thermo Fisher Scientific, Waltham, MA, USA). Clinicopathological variables were compared. Multivariable binary logistic regression analysis was performed to identify predictive factors for high 21-gene RS (≥26). In addition, we analyzed 356 patients with stage 1/2, ER+/PR+/HER2- breast cancer from TCGA database.

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