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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 54 - 54 (1page)
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Undaria pinnatifida (U. pinnatifida), a brown alga commonly grown in the oceans of East Asia, has long been a part of human diet and medicine. Though U. pinnatifida has been reported to have immunomodulatory, anti-inflammatory, anti-oxidant, anti-diabetic and anti-bacterial activities, its specific effect on allergic rhinitis (AR) disease has not been clarified. In this study, the anti-allergic and anti-inflammatory effects of U. pinnatifida extract (UPE) were investigated in a mouse model of ovalbumin (OVA)-induced AR. After UPE treatment, the nasal and lung allergy symptoms, nasal mucosal swelling, and goblet cell hyperplasia were obviously ameliorated. Oral UPE regulated the balance of T helper (Th) 1/Th2 and Th17/Treg cells differentiation in AR mice in a dose-dependent manner. Accordingly, UPE attenuated the expression of Th2 cytokines (IL-4, IL-5, IL-1 ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-511-001942152