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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.3
- 발행연도
- 2021.9
- 수록면
- 285 - 295 (11page)
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초록· 키워드
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Excess lipid intake can trigger liver lipid accumulation and oxidative responses, which can lead to metabolic disturbances and contribute to hepatic steatosis and obesity and increase the risk of cardiovascular disease. Production of fish oil rich in omega-3 is a good opportunity for valorizing fish by-products in the therapeutic field. In this study, we explored the effects of oil from Sardina pilchardus by-products on cardiometabolic and oxidative disorders caused by toxic effects of excess lipids in obese rats. Three groups of obese rats received either 20% sardine by-product oil (SBy-Ob-HS; experimental group), 20% fillet oil (SF-Ob-HS; positive control group), or a high-fat diet (Ob-HS). Normal weight rats received a standard diet (normal). There was a significant decrease in serum total cholesterol (TC), triacylglycerols (TG), and insulin concentrations in the SBy-Ob-HS group compared with the SF-Ob-HS group. Compared with the Ob-HS group, TC and TG, glycemia, glycosylated hemoglobin, and insulinemia were decreased in the SBy-Ob-HS (more notably) and SF-Ob-HS groups. Furthermore, hepatic lipids, low density lipoprotein-cholesterol (C), the non-esterified cholesterol/phospholipids ratio, serum transaminases activities and lipid peroxidation were lower and serum high density lipoproteins-C were higher in the SBy-Ob-HS and SF-Ob-HS groups compared with the Ob-HS group. Serum isoprostane concentrations were reduced in the SBy-Ob-HS (more notably) and SF-Ob-HS groups compared with the Ob-HS and normal groups. The activities of antioxidant enzymes in tissues were enhanced, particularly in the by-product oil group. The oil extracted from by-products demonstrate anti-obesity properties (hypolipemiant, hepatoprotective, antiatherogenic, antidiabetic, and antioxidant) that may be beneficial for the management of obesity and its complications, such as hepatic steatosis.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (65)
참고문헌 신청
Aebi H. / 1974 / Methods of Enzymatic Analysis / Academic Press, Inc :673~680
Affane F / 2018 / Sardine purified proteins improve blood pressure, glycemic control, anti-atherogenic metabolic pathways and antioxidant capacity in obese rats / Ann Cardiol Angeiol 67:154~160
Affane F / 2016 / Effects of an obesogenic diet enriched in sardine by-products on pro-atherogenic markers in Wistar rats / Ann Cardiol Angeiol 65:214~218
Affane F / 2018 / Hypolipidemic, antioxidant and antiatherogenic property of sardine by-products proteins in high-fat diet induced obese rats / Life Sci 199:16~22
Benyahia-Mostefaoui A / 2014 / Milk lipids and sardine oil intake modulate differently enzymatic antioxidant defense in rats fed an atherogenic diet / J Exp Integr Med 4:115~121
Affane F / 2018 / Sardine purified proteins improve blood pressure, glycemic control, anti-atherogenic metabolic pathways and antioxidant capacity in obese rats / Ann Cardiol Angeiol 67:154~160
Affane F / 2016 / Effects of an obesogenic diet enriched in sardine by-products on pro-atherogenic markers in Wistar rats / Ann Cardiol Angeiol 65:214~218
Affane F / 2018 / Hypolipidemic, antioxidant and antiatherogenic property of sardine by-products proteins in high-fat diet induced obese rats / Life Sci 199:16~22
Benyahia-Mostefaoui A / 2014 / Milk lipids and sardine oil intake modulate differently enzymatic antioxidant defense in rats fed an atherogenic diet / J Exp Integr Med 4:115~121
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