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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 132 - 132 (1page)
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Glioblastoma (GBM) is an incurable brain tumor with a median survival of fifteen months. Identifying the cell of origin that harbors mutations could provide a fundamental basis for understanding disease progression. In the 5-aminolevulinic acid (5-ALA) guided tumor resection for GBM, neurosurgeons have observed the tumor-free satellite showing 5-ALA positivity in the remote subventricular zone (SVZ) far from a primary tumor. Firstly, we hypothesized that neural stem cells (NSCs), with their self-renewal and proliferative capacities, in the SVZ of the adult human brain may be the cells from which GBM originates. From this hypothesis, we reported the direct molecular genetic evidence from patient brain tissue and genome-edited mouse models that show astrocyte-like NSCs in the SVZ to be the cell of origin that contains the driver mutations of human GBM. However, current treatment for GBM neglects the SVZ but focuses on only primary tumors, in ... 전체 초록 보기
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