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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 539 - 544 (6page)
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초록· 키워드
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Skin aging appears to be the result of overlapping intrinsic (including genetic and hormonal factors) and extrinsic (external environment including chronic light exposure, chemicals, and toxins) processes. These factors cause decreases in the synthesis of collagen type I and elastin in fibroblasts and increases in the melanin in melanocytes. Collagen Type I is the most abundant type of collagen and is a major structural protein in human body tissues. In previous studies, many products containing collagen derived from land and marine animals as well as other sources have been used for a wide range of purposes in cosmetics and food. However, to our knowledge, the effects of human collagenderived peptides on improvements in skin condition have not been investigated. Here we isolate and identify the domain of a human COL1A2-derived protein which promotes fibroblast cell proliferation and collagen type I synthesis. This human COL 1A2-derived peptide enhances wound healing and elastin production. Finally, the human collagen alpha-2 type I-derived peptide (SMM) ameliorates collagen type I synthesis, cell proliferation, cell migration, and elastin synthesis, supporting a significant anti-wrinkle effect. Collectively, these results demonstrate that human collagen alpha-2 type I-derived peptides is practically accessible in both cosmetics and food, with the goal of improving skin condition.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
El-Domyati M / 2002 / Intrinsic aging vs. photoaging : a comparative histopathological, immunohistochemical, and ultrastructural study of skin / Exp Dermatol 11:398~405
Ganceviciene R / 2012 / Skin anti-aging strategies / Dermatoendocrinol 4:308~319
Rendon MI / 2005 / Review of skin-lightening agents / Dermatol Surg 31:886~889
Petit L / 2003 / Skin-lightening products revisited / Int J Cosmet Sci 25:169~181
Kim WS / 2009 / Antiwrinkle effect of adipose-derived stem cell : activation of dermal fibroblast by secretory factors / J Dermatol Sci 53:96~102
Ganceviciene R / 2012 / Skin anti-aging strategies / Dermatoendocrinol 4:308~319
Rendon MI / 2005 / Review of skin-lightening agents / Dermatol Surg 31:886~889
Petit L / 2003 / Skin-lightening products revisited / Int J Cosmet Sci 25:169~181
Kim WS / 2009 / Antiwrinkle effect of adipose-derived stem cell : activation of dermal fibroblast by secretory factors / J Dermatol Sci 53:96~102
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